2-Methoxy-1-(pyridin-3-yl)ethan-1-one | 1248668-72-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methoxy-1-(pyridin-3-yl)ethan-1-one
• 英文别名: 2-methoxy-1-pyridin-3-ylethanone
• CAS: 1248668-72-5
• 化学式: C₈H₉NO₂
• 分子量: 151.16
• InChiKey: JLFQZGQFRIBTCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Novel Myocyte Enhancer Factor 2 (MEF2) modulators
  申请人：STANDARD LLC

  公开号：US20190241504A1

  公开（公告）日：2019-08-08

  The present disclosure provides novel compounds capable of functioning as Myoctye Enhancer Factor 2 (MEF2) modulators, as well as compositions, pharmaceutical formulations, methods of synthesis and kits. Also provided are methods of treating a condition regulatable by MEF2 and/or MEF2 cofactors using the compounds, compositions, pharmaceutical formulations, and kits provided herein.

  本公开提供了能够作为肌肉细胞增强因子2（MEF2）调节剂发挥作用的新化合物，以及组合物、药物配方、合成方法和试剂盒。还提供了使用本文提供的化合物、组合物、药物配方和试剂盒治疗可通过MEF2和/或MEF2辅因子调节的疾病的方法。
• Method of modulating stress-activated protein kinase system
  申请人：Blatt M. Lawrence

  公开号：US20060270612A1

  公开（公告）日：2006-11-30

  Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.

  本发明涉及使用活性化合物调节应激激活蛋白激酶（SAPK）系统的方法，该活性化合物对至少一种p38 MAPK的抑制作用具有低效性；并且所述接触是在低百分比抑制浓度下进行的SAPK调节浓度，以抑制化合物对至少一种p38 MAPK的作用。此外，本发明还涉及吡非酮的衍生物，这些衍生物可以调节SAPK系统。
• Methods of Treating Atrial Fibrillation with P38 Inhibitor Compounds
  申请人：Olgin Jeff

  公开号：US20100029578A1

  公开（公告）日：2010-02-04

  The invention disclosed herein relates generally to compounds and methods useful in treating or preventing atrial fibrillation (AF).

  本发明涉及通常用于治疗或预防房颤(AF)的化合物和方法。
• METHODS OF TREATING ATRIAL FIBRILLATION WITH P38 INHIBITOR COMPOUNDS
  申请人：Olgin Jeff

  公开号：US20120046321A1

  公开（公告）日：2012-02-23

  The invention disclosed herein relates generally to compounds and methods useful in treating or preventing atrial fibrillation (AF).

  本发明涉及一般与化合物和方法有关，用于治疗或预防心房颤动（AF）。
• METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM
  申请人：Blatt Lawrence M.

  公开号：US20120258924A1

  公开（公告）日：2012-10-11

  Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.

  本发明涉及使用活性化合物调节应激激活蛋白激酶（SAPK）系统的方法，其中该活性化合物对至少一种p38 MAPK抑制的效力较低；并且该接触是在该化合物对至少一种p38 MAPK的抑制浓度低百分比的SAPK调节浓度下进行的。本发明还涉及吡非尼酮的衍生物，这些衍生物可以调节应激激活蛋白激酶（SAPK）系统。