2-trans-pentenyl diphosphate | 929531-71-5

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: 2-trans-pentenyl diphosphate
• 英文别名: [(E)-pent-2-enyl] phosphono hydrogen phosphate
• CAS: 929531-71-5
• 化学式: C₅H₁₂O₇P₂
• 分子量: 246.094
• InChiKey: WZDSLOCYZQFUGM-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (R)-benzodiazepinedione 、 2-trans-pentenyl diphosphate 在 recombinant AnaPT 、 三羟甲基氨基甲烷盐酸盐 、 二甲基亚砜 、 甘油 、 calcium chloride 作用下， 反应 16.0h， 以26.8%的产率得到
  参考文献：
  名称：

  Breaking Cyclic Dipeptide Prenyltransferase Regioselectivity by Unnatural Alkyl Donors

  摘要：

  The behavior of five cyclic dipeptide prenyltransferases, responsible for C2-regular, C2-reverse, or C3-reverse prenylation, was investigated In the presence of the unnatural alkyl donors monomethylallyl and 2-pentenyl diphosphate. Both substrates were well accepted by the tested enzymes. Interestingly, C2-reverse and C3-reverse monoalkylated derivatives were identified as enzyme products In all of the enzyme assays. These findings indicate their similar reaction characteristics in the presence of unnatural alkyl donors.

  DOI：

  10.1021/ol401247s

文献信息

• Breaking Cyclic Dipeptide Prenyltransferase Regioselectivity by Unnatural Alkyl Donors
  作者：Mike Liebhold、Xiulan Xie、Shu-Ming Li

  DOI：10.1021/ol401247s

  日期：2013.6.21

  The behavior of five cyclic dipeptide prenyltransferases, responsible for C2-regular, C2-reverse, or C3-reverse prenylation, was investigated In the presence of the unnatural alkyl donors monomethylallyl and 2-pentenyl diphosphate. Both substrates were well accepted by the tested enzymes. Interestingly, C2-reverse and C3-reverse monoalkylated derivatives were identified as enzyme products In all of the enzyme assays. These findings indicate their similar reaction characteristics in the presence of unnatural alkyl donors.