1-chloro-3,3,4,4,4-pentafluoro-butan-2-one | 680-13-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-chloro-3,3,4,4,4-pentafluoro-butan-2-one
• 英文别名: 1-Chlor-3,3,4,4,4-pentafluor-butan-2-on；1-Chloro-3,3,4,4,4-pentafluorobutan-2-one
• CAS: 680-13-7
• 化学式: C₄H₂ClF₅O
• 分子量: 196.504
• InChiKey: NXKIFPNTRLCIFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  重氮甲烷 、 五氟丙酰氯 在 乙醚 作用下， 生成 1-chloro-3,3,4,4,4-pentafluoro-butan-2-one
  参考文献：
  名称：

  Suicidal behavior—symptom or disorder?

  摘要：

  This article examines the diagnostic status of suicidal ideation with and without additional signs of defined or subthreshold mental disorders. Data from the World Health Organization (WHO) study on Psychological Problems in General Health Care (PPGHC) show that 8.8% of all general practice patients report that they recently had a wish to be dead. Among patients with acute depressive episodes, the rate is 34.5%, as compared with 1.3% in persons without any sign of mental disorder. Rates of suicidal ideation in persons with subthreshold disorders (10.4%) are similar to the rate in persons with other, nondepressed forms of mental disorders (12.9%). Still, 30.1% of all persons with suicidal ideation do not have a defined mental disorder, and 21.5% do not even have subthreshold disorders. But in these persons also, suicidal ideation is associated with an increased rate of depressive complaints. Suicidal ideation therefore, in any case, can be seen as an indicator of mental problems. But it seems impossible to lower the thresholds of defined mental disorders so that all forms of suicidal ideation will be covered. Instead, suicidal thoughts must be regarded as a symptom with the status of a disorder itself which should be handled as a comorbid condition if other mental disorders co-occur, Copyright (C) 2000 by W.B. Saunders Company.

  DOI：

  10.1016/s0010-440x(00)80017-6