Bis<2-<(hydroxymethyl)benzyl>phenyl>methane | 152897-32-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: Bis<2-<(hydroxymethyl)benzyl>phenyl>methane
• CAS: 152897-32-0
• 化学式: C₂₉H₂₈O₂
• 分子量: 408.54
• InChiKey: SNFQNHRKXHAHEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.44
• 重原子数：
  31.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  40.46
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  Bis<2-<(hydroxymethyl)benzyl>phenyl>methane 在 Celite 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以93%的产率得到Bis<2-(2-formylbenzyl)phenyl>methane
  参考文献：
  名称：

  Orthocyclophanes. 2. Starands, a new family of macrocycles of spirobicyclic polyketals with a 2n-crown-n moiety

  摘要：

  Synthesis and functionalization of higher members of the [1n]orthocyclophanes, or [1n]OCPs, have been investigated. Oxidation of the benzylic methylenes in [1n]OCPs gave the polyoxo derivatives. Exhaustive oxidation of all methylenes in even-numbered [1n]OCPs gave rearranged isomers of the cyclopolyketal structure instead of the corresponding polyoxo derivatives. We propose the class name ''starands'' for this new family of crown compounds for their star-shaped crown ether structure. Detailed synthesis and characterization of two starands are described.

  DOI：

  10.1021/jo00077a044
• 作为产物：
  描述：

  双[(2-羟甲基)苯基]甲烷 在 copper(l) iodide 、 氢溴酸 、 对甲苯磺酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 10.0h， 生成 Bis<2-<(hydroxymethyl)benzyl>phenyl>methane
  参考文献：
  名称：

  Orthocyclophanes. 2. Starands, a new family of macrocycles of spirobicyclic polyketals with a 2n-crown-n moiety

  摘要：

  Synthesis and functionalization of higher members of the [1n]orthocyclophanes, or [1n]OCPs, have been investigated. Oxidation of the benzylic methylenes in [1n]OCPs gave the polyoxo derivatives. Exhaustive oxidation of all methylenes in even-numbered [1n]OCPs gave rearranged isomers of the cyclopolyketal structure instead of the corresponding polyoxo derivatives. We propose the class name ''starands'' for this new family of crown compounds for their star-shaped crown ether structure. Detailed synthesis and characterization of two starands are described.

  DOI：

  10.1021/jo00077a044

文献信息

• Orthocyclophanes. 2. Starands, a new family of macrocycles of spirobicyclic polyketals with a 2n-crown-n moiety
  作者：Woo Young Lee、Chang Hee Park

  DOI：10.1021/jo00077a044

  日期：1993.12

  Synthesis and functionalization of higher members of the [1n]orthocyclophanes, or [1n]OCPs, have been investigated. Oxidation of the benzylic methylenes in [1n]OCPs gave the polyoxo derivatives. Exhaustive oxidation of all methylenes in even-numbered [1n]OCPs gave rearranged isomers of the cyclopolyketal structure instead of the corresponding polyoxo derivatives. We propose the class name ''starands'' for this new family of crown compounds for their star-shaped crown ether structure. Detailed synthesis and characterization of two starands are described.