decyl 3-[4-(3,4,5-triacetyloxybenzoyloxy)-3-methoxyphenyl]-2-propenoate | 515835-77-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: decyl 3-[4-(3,4,5-triacetyloxybenzoyloxy)-3-methoxyphenyl]-2-propenoate
• CAS: 515835-77-5
• 化学式: C₃₃H₄₀O₁₁
• 分子量: 612.674
• InChiKey: NRROEUDUFWZTJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.39
• 重原子数：
  44.0
• 可旋转键数：
  17.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  140.73
• 氢给体数：
  0.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  decyl 3-[4-(3,4,5-triacetyloxybenzoyloxy)-3-methoxyphenyl]-2-propenoate 在 一水合肼 作用下， 以 乙腈 为溶剂， 反应 0.25h， 以83%的产率得到decyl 3-[4-(3,4,5-trihydroxybenzoyloxy)-3-methoxyphenyl]-2-propenoate
  参考文献：
  名称：

  Synthesis of Novel Polyphenols Consisted of Ferulic and Gallic Acids, and Their Inhibitory Effects on Phorbol Ester-Induced Epstein–Barr Virus Activation and Superoxide Generation

  摘要：

  We prepared novel polyphenols which were esters composed of two naturally occurring products, ferulic and gallic acids, and investigated their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus (EBV) activation and superoxide (O-2(-)) generation. Most of these compounds exhibited significant EBV activation suppression at a concentration of 20 muM and in particular, the ester 5f having 2-metyl-1-butyl group showed high activity. The suppressive effects on O-2(-) generation were also observed in most of the esters. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00361-3
• 作为产物：
  描述：

  3,4,5-三乙酸基苯甲酸 在 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 反应 4.0h， 生成 decyl 3-[4-(3,4,5-triacetyloxybenzoyloxy)-3-methoxyphenyl]-2-propenoate
  参考文献：
  名称：

  Synthesis of Novel Polyphenols Consisted of Ferulic and Gallic Acids, and Their Inhibitory Effects on Phorbol Ester-Induced Epstein–Barr Virus Activation and Superoxide Generation

  摘要：

  We prepared novel polyphenols which were esters composed of two naturally occurring products, ferulic and gallic acids, and investigated their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus (EBV) activation and superoxide (O-2(-)) generation. Most of these compounds exhibited significant EBV activation suppression at a concentration of 20 muM and in particular, the ester 5f having 2-metyl-1-butyl group showed high activity. The suppressive effects on O-2(-) generation were also observed in most of the esters. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00361-3