6'-Amino-2-oxo-1',3'-diphenyl-spiro<2,3-dihydro-indol-3,4'-pyrano<2,3-c>pyrazol>-5'-carbonitril | 138197-36-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6'-Amino-2-oxo-1',3'-diphenyl-spiro<2,3-dihydro-indol-3,4'-pyrano<2,3-c>pyrazol>-5'-carbonitril
• 英文别名: 6'-amino-2-oxo-1',3'-diphenylspiro[indoline-3,4'-pyrano[2,3-c]pyrazole]-5'-carbonitrile；6'-amino-2-oxo-1',3'-diphenylspiro[1H-indole-3,4'-pyrano[2,3-c]pyrazole]-5'-carbonitrile
• CAS: 138197-36-1
• 化学式: C₂₆H₁₇N₅O₂
• 分子量: 431.453
• InChiKey: SWZARCZNPNVPOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  33
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(2-氧杂环丁-3-亚基)丙二腈 、 2,4-二氢-2,5-二苯基-3H-吡唑啉-3-酮 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以64%的产率得到6'-Amino-2-oxo-1',3'-diphenyl-spiro<2,3-dihydro-indol-3,4'-pyrano<2,3-c>pyrazol>-5'-carbonitril
  参考文献：
  名称：

  Synthesen mit Nitrilen, 88. Mitt.: Spiro[indol- und Spiro[inden-pyrano[2,3-c]pyrazole]aus Cyanmethylenderivaten und Pyrazolonen

  摘要：

  The reactivity of cyanomethylene-indolones (1 a-e) and 2-(dicyanomethylene)-indan-1,3-dione (4) towards, 1,5-disubstituted 3-pyrazolones (2 a-c) was investigated. The reactions yield spiro[indene- and spiro[indole-4'- and 6'-pyrano[2,3-c]pyrazoles] (3 a-e, 5 a-c). The structures are proven by C-13-NMR-spectroscopy. The mechanisms of the reactions are discussed.

  DOI：

  10.1007/bf00811473

文献信息

• 4-Dimethylaminopyridine-catalyzed multi-component one-pot reactions for the convenient synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] derivatives
  作者：Jun Feng、Keyume Ablajan、Ahat Sali

  DOI：10.1016/j.tet.2013.11.019

  日期：2014.1

  reaction process was developed for the convenient and cheap synthesis of spirooxindole derivatives. One-pot reactions of isatins, malononitrile (or ethyl cyanoacetate), hydrazine hydrate (or phenylhydrazine), and 1,3-dicarbonyl compounds were compared with one-pot reactions of isatins, malononitrile (or ethyl cyanoacetate), and 5-pyrazolone derivatives. Both sets of reaction were conducted in EtOH in the

  开发了一种有效且清洁的反应过程，以方便且廉价地合成螺并吲哚衍生物。比较了靛红，丙二腈（或氰基乙酸乙酯），水合肼（或苯肼）和1，3-二羰基化合物的一锅法反应与靛红，丙二腈（或氰基乙酸乙酯）和5-吡唑啉酮衍生物的一锅法反应。 。两组反应均在4-DMAP催化剂存在下于EtOH中进行。使用四组分一锅法快速快速获得了一系列螺[吲哚啉-3,4'-吡喃并[2,3- c ]吡唑]衍生物。
• Synthesen mit Nitrilen, 88. Mitt.: Spiro[indol- und Spiro[inden-pyrano[2,3-c]pyrazole]aus Cyanmethylenderivaten und Pyrazolonen
  作者：Renate Dworczak

  DOI：10.1007/bf00811473

  日期：——

  The reactivity of cyanomethylene-indolones (1 a-e) and 2-(dicyanomethylene)-indan-1,3-dione (4) towards, 1,5-disubstituted 3-pyrazolones (2 a-c) was investigated. The reactions yield spiro[indene- and spiro[indole-4'- and 6'-pyrano[2,3-c]pyrazoles] (3 a-e, 5 a-c). The structures are proven by C-13-NMR-spectroscopy. The mechanisms of the reactions are discussed.