| 1021443-01-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1021443-01-5
• 化学式: C₁₉H₁₇NO₂
• 分子量: 291.349
• InChiKey: DBKACQJVRXCKPL-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 碘 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以69%的产率得到4-(4-Acetylphenyl)-3-iodo-1-methyl-8-methylidene-1-azaspiro[4.5]deca-3,6,9-trien-2-one
  参考文献：
  名称：

  Electrophilic ipso-Iodocyclization of N-(4-Methylphenyl)propiolamides: Selective Synthesis of 8-Methyleneazaspiro[4,5]trienes

  摘要：

  [GRAPHICS]A novel and selective method for the synthesis of 8-methylenespiro[4,5]trienes via intramolecular electrophilic ipsoiodocyclization of N-(4-methylphenyl)propiolamides has been developed. In the presence of ICI or I-2, 8-methylene-1-azaspiro[4,5]trienes were selectively prepared from the electrophilic ipso-iodocyclization of N-(4-methylphenyl)propiolamides in moderate to good yields.

  DOI：

  10.1021/jo800328a