Poly(oxy-1,2-ethanediyl), I+/--hydro-I-hydroxy-, ether with 2,2-bis[[3-hydroxy-2,2-bis(hydroxymethyl)propoxy]methyl]-1,3-propanediol (8:1) | 1309573-30-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Poly(oxy-1,2-ethanediyl), I+/--hydro-I-hydroxy-, ether with 2,2-bis[[3-hydroxy-2,2-bis(hydroxymethyl)propoxy]methyl]-1,3-propanediol (8:1)
• 英文别名: 2-[3-(2-hydroxyethoxy)-2-[[3-(2-hydroxyethoxy)-2-[[3-(2-hydroxyethoxy)-2,2-bis(2-hydroxyethoxymethyl)propoxy]methyl]-2-(2-hydroxyethoxymethyl)propoxy]methyl]-2-(2-hydroxyethoxymethyl)propoxy]ethanol
• CAS: 1309573-30-5
• 化学式: C₃₁H₆₄O₁₈
• 分子量: 724.8
• InChiKey: RXEWLYVIZSUJGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.4
• 重原子数：
  49
• 可旋转键数：
  40
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  254
• 氢给体数：
  8
• 氢受体数：
  18

文献信息

• Salt Form of a Multi-Arm Polymer-Drug Conjugate
  申请人：Chong Anthony O.

  公开号：US20130231359A1

  公开（公告）日：2013-09-05

  Among other aspects, provided herein is a hydrohalide salt of a multi-arm water-soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding free base form of the conjugate.

  本文提供了一种多臂水溶性聚乙二醇-药物结合物的氢卤化盐，以及相关的制备和使用方法。该氢卤化盐稳定形成，似乎比相应的自由碱基形式的结合物更抵抗水解降解。
• ACID SALT FORMS OF POLYMER-DRUG CONJUGATES AND ALKOXYLATION METHODS
  申请人：NEKTAR THERAPEUTICS

  公开号：US20150105519A1

  公开（公告）日：2015-04-16

  Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.

  本文提供了一种水溶性聚合物-药物共轭物的混酸盐，以及相关的制备和使用方法。该混合酸盐稳定形成，并且似乎比相应的纯酸盐或自由基形式的聚合物-药物共轭物更耐水解降解。混酸盐可重复制备和回收，并提供了比非混酸盐形式的水溶性聚合物药物共轭体更出乎意料的优势。
• ALKOXYLATION METHODS
  申请人：Nektar Therapeutics

  公开号：US20160200867A1

  公开（公告）日：2016-07-14

  Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.

  本文提供了一种水溶性聚合物药物结合物的混酸盐，以及相关的制备和使用方法。混酸盐稳定形成，似乎比相应的纯酸盐或游离基形式的聚合物药物结合物更具抗水解降解性。混酸盐可以被可重复地制备和回收，并且相比于水溶性聚合物药物结合物的非混酸盐形式，具有出乎意料的优势。
• Acid Salt Forms of Polymer-Drug Conjugates and Alkoxylation Methods
  申请人：Chong Anthony O.

  公开号：US20130143909A1

  公开（公告）日：2013-06-06

  Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.
• US9226969B2
  申请人：——

  公开号：US9226969B2

  公开（公告）日：2016-01-05