(Ξ)-Aepfelsaeure-4-(L-gulo-2,3,4,5-tetrahydroxy-6-oxo-hexylester) | 123128-59-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (Ξ)-Aepfelsaeure-4-(L-gulo-2,3,4,5-tetrahydroxy-6-oxo-hexylester)
• 英文别名: (Ξ)-Aepfelsaeure-4-(L-gulo-2,3,4,5-tetrahydroxy-6-oxo-hexylester)；6-((Ξ)-3-Carboxy-3-hydroxy-propionyl)-D-glucose
• CAS: 123128-59-6
• 化学式: C₁₀H₁₆O₁₀
• 分子量: 296.231
• InChiKey: OSZNPSXGEVAGDQ-GUSONKAWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.99
• 重原子数：
  20.0
• 可旋转键数：
  9.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  181.82
• 氢给体数：
  6.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  苹果酸 、 葡萄糖 在 水 作用下， 生成 (Ξ)-Aepfelsaeure-4-(L-gulo-2,3,4,5-tetrahydroxy-6-oxo-hexylester)
  参考文献：
  名称：

  Elevation of Serum Pro-Gastrin - Releasing Peptide in Patients with Medullary Thyroid Carcinoma and Small Cell Lung Carcinoma

  摘要：

  Medullary thyroid carcinoma (MTC) arises from parafollicular or C cells of the thyroid gland and produces a variety of peptides such as calcitonin (CT) and gastrin-releasing peptide (GRP). Here we measured serum levels of pro-gastrin-releasing peptide (Pro-GRP), a more stable precursor of GRP, in 15 patients with MTC (4 males, 11 females) who did not show any clinical or radiologic signs of small cell lung cancer. Serum Pro-GRP levels were elevated in 80% (12/15) patients. Significant correlation was observed between serum Pro-GRP and CT (r = 0.52) and carcinoembryonic antigen (CEA) (r = 0.56). Serum Pro-GRP levels also correlated with tumor size (r = 0.70). Serum Pro-GRP levels also decreased below the cut-off range in one patient after surgical resection. Our data suggest that Pro-GRP, which is considered to be a specific marker for small cell lung carcinoma, seems to be also helpful and additional marker for the diagnosis and monitoring the response to therapy in patients with MTC in addition to calcitonin as the main tumor marker.

  DOI：

  10.1089/105072501753271752