S-{2R-[(Formyl-hydroxy-amino)-methyl]-hexanoylamino}-2-phenyl acetic acid methyl ester | 234768-57-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: S-{2R-[(Formyl-hydroxy-amino)-methyl]-hexanoylamino}-2-phenyl acetic acid methyl ester
• 英文别名: methyl (2S)-2-[[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]amino]-2-phenylacetate
• CAS: 234768-57-1
• 化学式: C₁₇H₂₄N₂O₅
• 分子量: 336.388
• InChiKey: LCRBLFAAHOQQQY-CABCVRRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  95.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Cytostatic agents
  申请人：——

  公开号：US20030149084A1

  公开（公告）日：2003-08-07

  This invention provides a method of inhibiting proliferation of tumor cells in a subject by administering to the subject an effective amount of ester and thioester compounds containing an N-formyl hydroxylamine group. The compounds with which this invention is concerned thus represent a selection of a subclass from the compounds known in the art as MMP inhibitors, for a specific and previously unrecognized pharmaceutical utility in the inhibition of proliferation of rapidly dividing cells, including such tumor cells as lymphoma, leukemia, myeloma, adenocarcinoma, carcinoma, mesothelioma, teratocarcinoma, choriocarcinoma, small cell carcinoma, large cell carcinoma, melanoma, retinoblastoma, fibrosarcoma, leiomyosarcoma or endothelioma cells by a mechanism other than MMP inhibition.

  本发明提供了一种通过向受试者投予含有N-甲酰羟胺基的酯和硫酯化合物的有效量来抑制肿瘤细胞增殖的方法。本发明所涉及的化合物因此代表了一种从已知的MMP抑制剂化合物中选择的亚类，用于抑制快速分裂细胞的增殖，包括淋巴瘤、白血病、骨髓瘤、腺癌、癌瘤、间皮瘤、畸胎瘤、绒毛膜癌、小细胞癌、大细胞癌、黑色素瘤、视网膜母细胞瘤、纤维肉瘤、平滑肌肉瘤或内皮瘤细胞等肿瘤细胞，通过一种与MMP抑制不同的机制。
• CYTOSTATIC AGENTS
  申请人：BRITISH BIOTECH PHARMACEUTICALS LIMITED

  公开号：EP1054861A1

  公开（公告）日：2000-11-29
• N-FORMYL HYDROXYLAMINE DERIVATIVES AS ANTIBACTERIAL AGENTS
  申请人：BRITISH BIOTECH PHARMACEUTICALS LIMITED

  公开号：EP1140058A1

  公开（公告）日：2001-10-10
• ANTI-INFLAMMATORY AGENTS
  申请人：BRITISH BIOTECH PHARMACEUTICALS LIMITED

  公开号：EP1146868A1

  公开（公告）日：2001-10-24
• US6476067B1
  申请人：——

  公开号：US6476067B1

  公开（公告）日：2002-11-05