4-(3-hydroxymethyl-6,7-diethoxyisoquinolin-1-yl)-2-[7-(3,4,5-trimethoxyphenyl)thieno[2,3-d]pyridazin-4(5H)-on-5-yl]pyridine | 209261-50-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-(3-hydroxymethyl-6,7-diethoxyisoquinolin-1-yl)-2-[7-(3,4,5-trimethoxyphenyl)thieno[2,3-d]pyridazin-4(5H)-on-5-yl]pyridine
• 英文别名: 5-[4-[6,7-diethoxy-3-(hydroxymethyl)isoquinolin-1-yl]pyridin-2-yl]-7-(3,4,5-trimethoxyphenyl)thieno[2,3-d]pyridazin-4-one
• CAS: 209261-50-7
• 化学式: C₃₄H₃₂N₄O₇S
• 分子量: 640.717
• InChiKey: AMZBRVPRTGUJNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  46
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  153
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  2-Hydrazino-4-(3-hydroxymethyl-6,7-diethoxyisoquinolin-1-yl)pyridine 、 2-(3,4,5-Trimethoxybenzoyl)-3-thiophenecarboxylic acid 以to give 4-(3-hydroxymethyl-6,7-diethoxyisoquinolin-1-yl)-2-[7-(3,4,5-trimethoxyphenyl)thieno[2,3-d]pyridazin-4(5H)-on-5-yl]pyridine的产率得到4-(3-hydroxymethyl-6,7-diethoxyisoquinolin-1-yl)-2-[7-(3,4,5-trimethoxyphenyl)thieno[2,3-d]pyridazin-4(5H)-on-5-yl]pyridine
  参考文献：
  名称：

  Pyridine derivatives

  摘要：

  化合物的化学式为(I)：## STR1 ## 其中A是以下公式的一种：## STR2 ##（其中R1和R2分别为H，或保护或未保护的OH，R31，R41和R42为保护或未保护的羟甲基，R32为H，低级烷基，或保护或未保护的羟甲基，R33为取代或未取代的低级烷基，虚线表示双键的存在或不存在），R5和R6为H，或保护或未保护的氨基，或与相邻的氮结合形成取代或未取代的杂环，或其药学上可接受的盐。这些化合物表现出卓越的支气管收缩抑制活性和/或气道抗炎活性，并可用于哮喘的预防或治疗。

  公开号：

  US05965730A1

文献信息

• Pharmaceutical pyridine derivatives, processes for preparing the same and intermediates therefor
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0848000A1

  公开（公告）日：1998-06-17

  A pyridine derivative of the formula (I): wherein A is group of the following formulae: R1 and R2 are each H, or protected or unprotected OH, R31, R41 and R42 are protected or unprotected hydroxymethyl, R32 is H, lower alkyl, or protected or unprotected hydroxymethyl, R33 is substituted or unsubstituted lower alkyl, and the dotted line means the presence or absence of a double bond' R5 and R6 are H, or protected or unprotected amino, or both combine together with the adjacent nitrogen to form substituted or unsubstituted heterocycle, or a pharmaceutically acceptable salt thereof, show excellent bronchoconstriction inhibitory activity and/or anti-inflammatory activity of airways, and are , useful in the prophylaxis or treatment of asthma.

  式（I）的吡啶衍生物： 其中 A 为下式中的基团： R1 和 R2 分别为 H，或受保护或未受保护的 OH，R31、R41 和 R42 为受保护或未受保护的羟甲基，R32 为 H、低级烷基或受保护或未受保护的羟甲基，R33 为取代或未取代的低级烷基，虚线表示存在或不存在双键' R5 和 R6 为 H、或受保护或未受保护的氨基，或两者与相邻的氮结合在一起形成取代或未取代的杂环，或其药学上可接受的盐，显示出优异的支气管收缩抑制活性和/或气道抗炎活性，可用于预防或治疗哮喘。
• Composition for regenerative treatment of cartilage disease
  申请人：Takigawa Masaharu

  公开号：US20070155652A1

  公开（公告）日：2007-07-05

  A composition for regenerative treatment of cartilage disease, which comprises a PDE4 inhibitor as an active ingredient, specifically a composition comprising a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suited to administer locally to affected cartilage region, such as microsphere preparation, can provide a pharmaceutical composition showing an excellent effect in regenerative treatment of cartilage.
• Composition for accelerating bone fracture healing
  申请人：Sakurai Naoki

  公开号：US20080031958A1

  公开（公告）日：2008-02-07

  A composition for accelerating fracture healing, which has a PDE4 inhibitor as an active ingredient, specifically a composition having a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suitable for local administration such as a microsphere preparation, can provide a pharmaceutical composition showing an excellent effect in the early healing of bone fracture. The composition is useful in healing of refractory fracture of elderly people and diabetic or osteoporosis patients.
• COMPOSITION FOR REGENERATIVE TREATMENT OF CARTILAGE DISEASE
  申请人：TAKIGAWA Masaharu

  公开号：US20100226993A1

  公开（公告）日：2010-09-09

  A composition for regenerative treatment of cartilage disease, which comprises a PDE4 inhibitor as an active ingredient, specifically a composition comprising a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suited to administer locally to affected cartilage region, such as microsphere preparation, can provide a pharmaceutical composition showing an excellent effect in regenerative treatment of cartilage.
• US5965730A
  申请人：——

  公开号：US5965730A

  公开（公告）日：1999-10-12