tert-butyl (6-methyl-5-nitropyridin-2-yl)carbamate | 1062134-25-1

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: tert-butyl (6-methyl-5-nitropyridin-2-yl)carbamate
• 英文别名: tert-butyl N-(6-methyl-5-nitropyridin-2-yl)carbamate
• CAS: 1062134-25-1
• 化学式: C₁₁H₁₅N₃O₄
• 分子量: 253.258
• InChiKey: VSNSCGBZXFVXBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  97
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P330,P363,P501
• 危险性描述：
  H302,H312,H332

反应信息

• 作为反应物：
  描述：

  tert-butyl (6-methyl-5-nitropyridin-2-yl)carbamate 在 palladium 10% on activated carbon 、 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 20.0h， 生成 tert-butyl (5-(3,4-dichlorobenzamido)-6-methylpyridin-2-yl)carbamate
  参考文献：
  名称：

  [EN] OCT4 HIGH-SELECTIVITY ACTIVATOR
  [FR] ACTIVATEUR D'OCT4 À SÉLECTIVITÉ ÉLEVÉE
  [ZH] OCT4高选择性活化剂

  摘要：

  可用于OCT4 及下游基因表达的高选择性活化剂，其药物组合物、其制备方法，所述活化剂具有下式：

  公开号：

  WO2022266794A1
• 作为产物：
  描述：

  2-氨基-6-甲基吡啶 在 4-二甲氨基吡啶 、 硫酸 、 硝酸 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 生成 tert-butyl (6-methyl-5-nitropyridin-2-yl)carbamate
  参考文献：
  名称：

  Identification of novel inhibitors of Aurora A with a 3-(pyrrolopyridin-2-yl)indazole scaffold

  摘要：

  A novel series of 3-(pyrrolopyridin-2-yl)indazole derivatives were synthesized and biologically evaluated for their anti-proliferative effects on five human cancer cell lines. As a result, all of them exhibited vigorous potency against HL60 cell line with IC50 values ranging from singe digital nanomolar to micromolar level. Besides, a majority of them displayed modest to good antiproliferative activities against the other four cell lines, including KB, SMMC-7721, HCT116, and A549. Particularly, compound 2y, as the most distinguished one in this series, demonstrated IC50 values of 8.3 nM and 1.3 nM against HL60 and HCT116 cell lines, respectively. Afterwards, for exploring the molecular target, compounds 2d, 2g and 2y were further selected to evaluate the inhibitory activities against a panel of kinases. Finally, they were identified to be targeting Aurora A kinase with significant selectivity over other kinases, such as CHK1, CDK2, MEK1, GSK3 beta, BRAF, IKK beta and PKC. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.02.004

文献信息

• Synthesis and Antiviral Activity Evaluation of some Novel Acyclic C-Nucleosides
  作者：Nikolaos Lougiakis、Panagiotis Marakos、Nicole Poul、Jan Balzarini

  DOI：10.1248/cpb.56.775

  日期：——

  The preparation of novel 5-amino or 7-hydroxy substituted pyrazolo[4,3-b]pyridine and pyrazolo[3,4-c]pyridine acyclic C-nucleosides is described. Their synthesis was carried out by condensation of suitably substituted lithiated picolines with 2-benzyloxyethoxymethylchloride followed by pyrazole ring annulation. The compounds were evaluated for their antiviral activity against a wide panel of viruses

  描述了新颖的5-氨基或7-羟基取代的吡唑并[4，3-b]吡啶和吡唑并[3，4-c]吡啶无环C-核苷的制备。它们的合成是通过适当取代的锂甲基吡啶与2-苄氧基乙氧基甲基氯化物的缩合，然后进行吡唑环环化来进行的。评估了这些化合物对多种病毒的抗病毒活性，但发现它们在亚毒性浓度下无活性。
• CN115572256
  申请人：——

  公开号：——

  公开（公告）日：——
• CN115572285
  申请人：——

  公开号：——

  公开（公告）日：——