10-(4-methoxy-phenyl)-decanoic acid | 35501-11-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 10-(4-methoxy-phenyl)-decanoic acid
• 英文别名: 10-(4-Methoxy-phenyl)-decansaeure；10-(p-Methoxyphenyl)-decansaeure；10-(4-methoxyphenyl)decanoic acid
• CAS: 35501-11-2
• 化学式: C₁₇H₂₆O₃
• 分子量: 278.392
• InChiKey: HATJICYEYQTZDR-UHFFFAOYSA-N

物化性质

• 沸点：
  424.7±18.0 °C(Predicted)
• 密度：
  1.019±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.44
• 重原子数：
  20.0
• 可旋转键数：
  11.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  10-(4-methoxy-phenyl)-decanoic acid 在 氯化亚砜 作用下， 生成 α-Chlormethyl-(ω-p-methoxyphenyl)-nonyl-keton
  参考文献：
  名称：

  Intramolecular base-catalyzed imidazole catalysis

  摘要：

  DOI：

  10.1021/ja00754a051
• 作为产物：
  描述：

  癸二酸 在 sodium hydroxide 、 一水合肼 作用下， 以 二乙二醇 为溶剂， 反应 2.0h， 生成 10-(4-methoxy-phenyl)-decanoic acid
  参考文献：
  名称：

  Intramolecular base-catalyzed imidazole catalysis

  摘要：

  DOI：

  10.1021/ja00754a051

文献信息

• Fieser et al., Journal of the American Chemical Society, 1948, vol. 70, p. 3177
  作者：Fieser et al.

  DOI：——

  日期：——
• X-Ray Diagnostics. II. Cholecystographic Agents¹
  作者：Domenick Papa、Erwin Schwenk、Hilda Breiger、Virginia Peterson

  DOI：10.1021/ja01162a077

  日期：1950.6
• Left ventricular diastolic function abnormalities in hypopituitary patients with GH deficiency: Evidence for a subclinical cardiomyopathy
  作者：N. Özbey、A. Sezgil、H. Oflaz、B. Umman、Y. Orhan、E. Sencer、S. Molvalilar

  DOI：10.1007/bf03345081

  日期：2002.7

  The aim of this study was to evaluate cardiac performance, in particular diastolic function, in adult patients with adulthood onset GH deficiency. The study group was composed of 19 GH deficient adult hypopituitary patients with at-least 3 additional pituitary hormone deficits and 19 age, sex and BMI matched healthy controls. Mean duration of hypopituitarism was 108.6 +/- 77.0 months. None of the patients and controls presented with or had previous diagnosis of concomitant diseases that could affect cardiac function. All hormone deficiencies, except for GH, were appropriately replaced in the patients. Left ventricular function and geometry were evaluated by two-dimensional, M-mode and Doppler echocardiography. Body composition was evaluated by bioelectrical impedance analysis. Not significant differences were observed with respect to left heart dimensions and left ventricular systolic function between patients and controls. Nevertheless 2 of the left ventricular diastolic function parameters, deceleration time and isovolumetric relaxation time, were significantly prolonged in the patients compared with controls (247.88 +/- 70.65 vs 143.26 +/- 31.70 milliseconds (ms) and 122.31 +/- 18.24 vs 89.47 +/- 12.12 ms respectively, p<0.001). Duration of hypopituitarism was significantly correlated with percent body fat mass (r=0.6119, p<0.01) and percent lean body mass (r=-0.5949, p<0.01). It is concluded that in adults affected by hypopituitarism, GH deficiency predominantly impairs diastolic function while systolic function at rest is spared. This observation might indicate a preclinical stage of a cardiomyopathy.