1-(2-hydroxyphenyl)-2-[3-(2-hydroxyphenyl)-6-methoxy-1H-indol-1-yl]ethanone | 1609489-54-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-hydroxyphenyl)-2-[3-(2-hydroxyphenyl)-6-methoxy-1H-indol-1-yl]ethanone
• 英文别名: 1-(2-Hydroxyphenyl)-2-[3-(2-hydroxyphenyl)-6-methoxyindol-1-yl]ethanone
• CAS: 1609489-54-4
• 化学式: C₂₃H₁₉NO₄
• 分子量: 373.408
• InChiKey: IFPYPSVKLDSNPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  71.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Indole derivatives, pharmaceutical compositions containing such indoles and their use as DNA methylation modulators
  申请人：Ikerchem, S.L.

  公开号：EP2730558A1

  公开（公告）日：2014-05-14

  The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer hematological malignancy, proliferative diseases, genetic diseases, neurological disorders and immunological disorders.

  本发明涉及式(I)的化合物，以及它们的制备方法、包含相同化合物的药物组合物，以及用于治疗和/或化学预防癌症、血液恶性肿瘤、增殖性疾病、遗传疾病、神经系统疾病和免疫系统疾病的用途。
• [EN] INDOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS DNA METHYLATION MODULATORS<br/>[FR] DÉRIVÉS D'INDOLES, COMPOSITIONS PHARMACEUTIQUES CONTENANT DE TELS INDOLES ET LEUR UTILISATION EN TANT QUE MODULATEURS DE LA MÉTHYLATION DE L'ADN
  申请人：IKERCHEM S L

  公开号：WO2014072371A1

  公开（公告）日：2014-05-15

  The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer hematological malignancy, proliferative diseases, genetic diseases, neurological disorders and immunological disorders.

  本发明涉及公式(I)的化合物，以及它们的制备方法、包含它们的制药组合物，以及用于治疗和/或化学预防癌症、血液恶性肿瘤、增生性疾病、遗传疾病、神经系统疾病和免疫系统疾病的用途。
• INDOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS DNA METHYLATION MODULATORS
  申请人：IKERCHEM, S.L.

  公开号：US20150336889A1

  公开（公告）日：2015-11-26

  The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer hematological malignancy, proliferative diseases, genetic diseases, neurological disorders and immunological disorders.

  本发明涉及公式（I）的化合物，以及它们的制备方法，包括这些化合物的药物组合物，以及它们用于治疗和/或化学预防癌症、血液恶性肿瘤、增殖性疾病、遗传性疾病、神经系统疾病和免疫系统疾病的用途。