2,2,7,7-Tetramethyloctan-4-one | 16387-37-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2,7,7-Tetramethyloctan-4-one
• CAS: 16387-37-4
• 化学式: C₁₂H₂₄O
• 分子量: 184.322
• InChiKey: GVELOCUNGAZLPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5-氟乳清酸一水合物 在 臭氧 作用下， 以 二氯甲烷 为溶剂， 以58%的产率得到2,2,7,7-Tetramethyloctan-4-one
  参考文献：
  名称：

  Mechanisms of epoxidation during ozonation of carbon-carbon double bonds

  摘要：

  DOI：

  10.1021/jo00202a015

文献信息

• SULFAMIDE DERIVATIVE HAVING AN ADAMANTYL GROUP AND ITS PHARMACEUTICALLY ACCEPTABLE SALT
  申请人：Kim Ki Young

  公开号：US20140024636A1

  公开（公告）日：2014-01-23

  Provided is a sulfamide derivative having an adamantyl group represented by the following Formula 1, or a pharmaceutically acceptable salt thereof. The sulfamide derivative suppresses the activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), and is useful in the treatment of various diseases that are mediated by 11β-HSD1.

  提供一个具有金刚烷基团的磺酰胺衍生物，其由以下公式1表示，或其药物可接受的盐。该磺酰胺衍生物抑制11β-羟基类固醇脱氢酶1（11β-HSD1）的活性，并且在治疗由11β-HSD1介导的各种疾病中是有用的。
• PROTEIN KINASE INHIBITORS AND USE THEREOF
  申请人：Askew Benny C.

  公开号：US20110282056A1

  公开（公告）日：2011-11-17

  Disclosed are compounds according to Formula I: wherein the variables are described herein.

  根据以下公式I披露了化合物：其中变量如本文所述。
• DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES
  申请人：CORNELL UNIVERSITY

  公开号：US20170121366A1

  公开（公告）日：2017-05-04

  The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R 1 -R 10 , X, Y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.

  本发明的化合物由以下具有式（I）的化合物表示，其中取代基R1-R10、X、Y、k、m、n、q和s的定义如本文所述。这些化合物用于治疗癌症、免疫紊乱、自身免疫性疾病、神经退行性疾病或炎症性疾病，或用于为移植的器官或组织提供免疫抑制。
• TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Babu Srinivasan

  公开号：US20110201593A1

  公开（公告）日：2011-08-18

  The invention provides novel compounds of formula I having the general formula: wherein R 1 , R 2 , R 3 , X and Y are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.

  本发明提供了具有以下一般式的新化合物I： 其中R1、R2、R3、X和Y如本文所述。因此，这些化合物可以在药学上可接受的组合物中提供，并用于治疗免疫或过度增生性疾病。
• IDENTIFICATION AND USE OF SMALL MOLECULES TO MODULATE TRANSCRIPTION FACTOR FUNCTION AND TO TREAT TRANSCRIPTION FACTOR ASSOCIATED DISEASES
  申请人：Oettgen Peter

  公开号：US20110071142A1

  公开（公告）日：2011-03-24

  The present invention relates to methods of identifying small molecule candidate agents capable of modulating transcription factor function such that the function/expression of a target transcription factor and/or proteins downstream of this target protein comprises the screening of small molecule libraries using in silico high throughput docking for candidate small molecules/agents that are selectively identified for their ability to target and disrupt the transcription factor-DNA interface through unique transcription factor and/or DNA descriptors that are defined within a pharmacophore, and then testing/evaluating the candidate agents identified above through one or more in vitro assays for their ability to modulate transcription factor function including expression of this target protein and/or proteins that are downstream of the target transcription factor. The present invention also relates to various compounds described herein (e.g., a compound of Formula XI), their pharmaceutically acceptable salts and to methods of using said compounds as described herein.