2-(1H-indol-3-yl)-N-[2-[2-[[2-(1H-indol-3-yl)acetyl]amino]ethylamino]ethyl]acetamide | 352205-18-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(1H-indol-3-yl)-N-[2-[2-[[2-(1H-indol-3-yl)acetyl]amino]ethylamino]ethyl]acetamide
• CAS: 352205-18-6
• 化学式: C₂₄H₂₇N₅O₂
• 分子量: 417.511
• InChiKey: RQJNSBHSBFDTBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  102
• 氢给体数：
  5
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-吲哚乙酸 、 二乙烯三胺 在 三乙胺 、 焦碳酸二乙酯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以80%的产率得到2-(1H-indol-3-yl)-N-[2-[2-[[2-(1H-indol-3-yl)acetyl]amino]ethylamino]ethyl]acetamide
  参考文献：
  名称：

  Highly selective and sensitive fluorescent chemosensor for Hg2+ in aqueous solution

  摘要：

  A new indole-based fluorescent chemosensor 1 was prepared and its metal ion sensing properties were investigated. It exhibits high sensitivity and selectivity toward He among a series of metal ions in H2O-EtOH (7:1, v/v). The association constant of the 1:1 complex formation for 1-Hg2+ was calculated to be 9.57 x 10(3) M-1, and the detection limit for Hg2+ was found to be 2.25 x 10(-5) M. Computational results revealed that 1 and Hg2+ ion formed with a central tetrahedron-coordinated He2+. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.110

文献信息

• [EN] AROMATIC AMIDES ACTING ON MELANOCORTIN RECEPTORS<br/>[FR] AMIDES AROMATIQUES AGISSANT SUR LES RECEPTEURS DE LA MELANOCORTINE
  申请人：MELACURE THERAPEUTICS AB

  公开号：WO2001055109A1

  公开（公告）日：2001-08-02

  The present invention relates to novel aromatic amides of formula (I) and to the use of these amides for the treatment of obesity, anorexia, inflammation, mental disorders and other diseases associated with the melanocortin receptors or related systems, e.g. the melanocyte stimulating hormones.
• Highly selective and sensitive fluorescent chemosensor for Hg2+ in aqueous solution
  作者：Hsiu-Han Wu、Yao-Lin Sun、Chin-Feng Wan、Shih-Tse Yang、Shau-Jiun Chen、Ching-Han Hu、An-Tai Wu

  DOI：10.1016/j.tetlet.2011.12.110

  日期：2012.2

  A new indole-based fluorescent chemosensor 1 was prepared and its metal ion sensing properties were investigated. It exhibits high sensitivity and selectivity toward He among a series of metal ions in H2O-EtOH (7:1, v/v). The association constant of the 1:1 complex formation for 1-Hg2+ was calculated to be 9.57 x 10(3) M-1, and the detection limit for Hg2+ was found to be 2.25 x 10(-5) M. Computational results revealed that 1 and Hg2+ ion formed with a central tetrahedron-coordinated He2+. (C) 2011 Elsevier Ltd. All rights reserved.