sorbitan monooleate | 73398-88-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: sorbitan monooleate
• 英文别名: Hexitol, 1,4-anhydro-, mono-(9Z)-9-octadecenoate；[2-(3,4-dihydroxyoxolan-2-yl)-2-hydroxyethyl] (Z)-octadec-9-enoate
• CAS: 73398-88-6
• 化学式: C₂₄H₄₄O₆
• 分子量: 428.61
• InChiKey: NWGKJDSIEKMTRX-KTKRTIGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  30
• 可旋转键数：
  19
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

ADMET

毒理性

• 人类毒性摘录

人类已无限制地被喂食单次剂量20克或每日剂量6克，持续1个月。/山梨坦单硬脂酸酯/

...MAN HAS BEEN FED WITH IMPUNITY SINGLE DOSES OF 20 G OR DAILY DOSES OF 6 G FOR 1 MONTH. /SORBITAN MONOSTEARATE/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

一名中老年男性因职业相关接触泊洛沙姆（山梨醇单油酸酯）而患上了接触性皮炎。

A MIDDLE AGED MALE DEVELOPED OCCUPATIONALLY RELATED CONTACT ECZEMA TO SORBITAN MONOOLEATE.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

没有已知的一次口服剂量对实验室动物是致命的.../司坦醇单硬脂酸酯/

NO SINGLE ORAL DOSE IS KNOWN TO BE LETHAL IN LABORATORY ANIMALS... /SORBITAN MONOSTEARATE/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

15只雄性和15只雌性大鼠被分别饲养，它们的饮食中分别含有0、2.5%、5%或10%的Span 80，持续16周。这导致雌性大鼠在摄入5%或10%的Span 80后，肾脏重量显著增加，并与肾小管发生不明病理意义的改变相关。在饮食水平最高的雄性和雌性大鼠中发现了肝脏肿大。在雌性大鼠中，这种效果与门脉周围脂肪变性有关。在摄入5%或10%的组中观察到了体重增加减少，但这主要是由于饮食的不适口性。

GROUPS OF 15 MALE & 15 FEMALE RATS WERE MAINTAINED ON A DIET CONTAINING 0, 2.5, 5 OR 10% SPAN 80 FOR 16 WK WHICH RESULTED IN SIGNIFICANTLY INCR KIDNEY WT, ASSOC IN THE FEMALE GROUPS GIVEN 5 OR 10% WITH TUBULAR CHANGES OF UNCERTAIN PATHOLOGICAL SIGNIFICANCE. LIVER ENLARGEMENT WAS FOUND IN THE MALES & FEMALES ON THE HIGHEST DIETARY LEVEL. IN THE FEMALES THIS EFFECT WAS ASSOC WITH PERIPORTAL FATTY CHANGE. REDUCED WT GAIN WAS OBSERVED IN GROUPS GIVEN 5 OR 10%, BUT THIS WAS DUE LARGELY TO THE UNPALATABILITY OF THE DIET.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

当被消化时，脂肪酸和多元醇山梨坦都被吸收，但后者完全通过尿液排出。/山梨坦单硬脂酸酯/

WHEN DIGESTED, BOTH THE FATTY ACID & THE POLYHYDRIC ALCOHOL SORBITAN ARE ABSORBED, BUT THE LATTER IS COMPLETELY EXCRETED IN URINE. /SORBITAN MONOSTEARATE/

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  丙烯酸 、 sorbitan monooleate 在 对甲苯磺酸 、 对苯二酚 作用下， 以 甲苯 为溶剂， 生成
  参考文献：
  名称：

  Fabrication and characterization of novel macroporous hydrogels based on the polymerizable surfactant AAc-Span80 and their enhanced drug-delivery capacity

  摘要：

  PNIPAM-co-AAc-Span80 疏水性增强，孔隙结构丰富，对 DOX 具有良好的吸附性能。解吸结果表明，98.7% 的 DOX 可在酸性环境中有效释放。

  DOI：

  10.1039/d2ra02443h

文献信息

• LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY ELEMENT
  申请人：JNC Corporation

  公开号：EP3275973A1

  公开（公告）日：2018-01-31

  Subject The subject is to provide a liquid crystal composition that includes a polymerizable compound (or polymer) and a polar compound, where the homeotropic alignment of liquid crystal molecules can be achieved by the action of these compounds, and a liquid crystal display device including this composition. This composition satisfies at least one of characteristics such as a high maximum temperature, a low minimum temperature, a small viscosity, a suitable optical anisotropy, a large positive dielectric anisotropy, a large specific resistance, a high stability to ultraviolet light or heat or a large elastic constant, or is suitably balanced regarding at least two of the characteristics. The means concerns a nematic liquid crystal composition that has positive dielectric anisotropy and that includes a polymerizable compound as an first additive and a polar compound as a second additive, and the composition may include a specific liquid crystal compound having a large positive dielectric anisotropy and a specific liquid crystal compound having a high maximum temperature or a small viscosity, and concerns a liquid crystal display device including the composition.

  主题 本课题旨在提供一种液晶组合物，其中包括一种可聚合化合物（或聚合物）和一种极性化合物，通过这些化合物的作用可实现液晶分子的各向同性排列，并提供一种包括这种组合物的液晶显示装置。这种组合物至少满足以下一种特性，如最高温度高、最低温度低、粘度小、光学各向异性合适、正介电各向异性大、比电阻大、对紫外线或热的稳定性高或弹性常数大，或至少在其中两种特性方面适当平衡。 该手段涉及一种具有正介电常数的向列液晶组合物，该组合物包括作为第一添加剂的可聚合化合物和作为第二添加剂的极性化合物，该组合物可包括具有较大正介电常数的特定液晶化合物和具有较高最高温度或较小粘度的特定液晶化合物，还涉及一种包括该组合物的液晶显示设备。
• Compounds and compositions comprising such compounds for the prevention or treatment of dyslipidaemias
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US10231985B2

  公开（公告）日：2019-03-19

  The present invention relates to the field of medicine. It more particularly relates to the use of compounds for preventing and/or treating dyslipidemia in a subject, said dyslipidemia typically being linked to the excess presence in the biological membranes, including in the biological membranes of non-adipocyte cells, of fatty acids, in particular of saturated long-chain fatty acids, and/or of sterols. The invention also relates to compositions, in particular pharmaceutical compositions and food supplements or complements, comprising such compounds, and to the uses thereof for preventing and/or treating dyslipidemia. The compounds and compositions according to the invention can in particular be advantageously used for preventing and/or treating a pathological condition selected from metabolic syndrome and/or a symptom or abnormality characteristic of metabolic syndrome, preferably for preventing or treating type 2 diabetes mellitus or hepatic steatosis.

  本发明涉及医学领域。所述血脂异常通常与生物膜（包括非脂肪细胞的生物膜）中脂肪酸（尤其是饱和长链脂肪酸）和/或甾醇的过量存在有关。本发明还涉及包含此类化合物的组合物，特别是药物组合物和食品补充剂或补品，以及其在预防和/或治疗血脂异常方面的用途。根据本发明的化合物和组合物尤其可有利地用于预防和/或治疗选自代谢综合征和/或代谢综合征特征性症状或异常的病理状况，最好用于预防或治疗 2 型糖尿病或肝脂肪变性。
• Liquid crystal composition and liquid crystal display device
  申请人：JNC CORPORATION

  公开号：US10479940B2

  公开（公告）日：2019-11-19

  A liquid crystal compound having positive dielectric anisotropy is provided and contains a compound represented by formula (1) as a first component, a compound represented by formula (2) as a second component, a polar compound as a first additive and a polymerizable compound as a second additive. In formula (1), R1a is alkyl having 1 to 12 carbons, or the like; ring Q and ring S are independently 1,4-cyclohexylene, 1,4-phenylene or the like; Z1a and Z2a are independently a single bond or the like; X1a and X2a are independently hydrogen or fluorine; Y1a is fluorine, chlorine, alkyl having 1 to 12 carbons in which at least one hydrogen is replaced by fluorine or chlorine, or the like; q is 1, 2, 3 or 4; s is 0, 1, 2 or 3; and a sum of q and s is 4 or less.

  提供了一种具有正介电常数各向异性的液晶化合物，它包含作为第一组分的式 (1) 所代表的化合物、作为第二组分的式 (2) 所代表的化合物、作为第一添加剂的极性化合物和作为第二添加剂的可聚合化合物。 在式 (1) 中，R1a 是具有 1 至 12 个碳原子的烷基或类似物；环 Q 和环 S 独立地为 1，4-环己烯、1，4-亚苯基或类似物；Z1a 和 Z2a 独立地为单键或类似物；X1a 和 X2a 独立地为氢或氟；Y1a 是氟、氯、具有 1 至 12 个碳原子的烷基（其中至少有一个氢原子被氟或氯取代）或类似物；q 是 1、2、3 或 4；s 是 0、1、2 或 3；q 和 s 的总和是 4 或更少。
• FLÜSSIGKRISTALLANZEIGEN MIT HOMÖOTROPER AUSRICHTUNG
  申请人：Merck Patent GmbH

  公开号：EP2670818B1

  公开（公告）日：2016-10-05
• LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：JNC Corporation

  公开号：EP3275973B1

  公开（公告）日：2019-12-18