2,4-Dimethoxy-5-fluorpyridin | 41935-73-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,4-Dimethoxy-5-fluorpyridin
• 英文别名: 2,4-Dimethoxy-5-fluoropyridine；5-fluoro-2,4-dimethoxypyridine
• CAS: 41935-73-3
• 化学式: C₇H₈FNO₂
• 分子量: 157.144
• InChiKey: GZVZHEQUEIUHQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] 5-ALKOXY[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE-2(3H)-THIONE COMPOUNDS AND THEIR USE IN THE PREPARATION OF 2,2'-DITHIOBIS(5-ALKOXY[1,2,4]TRIAZOLO[1,5-C]-PYRIMIDINE) AND 2-CHLOROSULFONYL-5-ALKOXY[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE COMPOUNDS<br/>[FR] COMPOSES 5-ALCOXY[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE-2(3H)-THIONE ET LEUR UTILISATION DANS LA PREPARATION DE COMPOSES 2,2'-DITHIOBIS(5-ALCOXY[1,2,4]TRIAZOLO[1,5-C]-PYRIMIDINE) ET 2-CHLOROSULFONYLE-5-ALCOXY[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE
  申请人：DOWELANCO

  公开号：WO1995012596A1

  公开（公告）日：1995-05-11

  (EN) 2-Chlorosulfonyl-5-alkoxy(1,2,4)triazolo(1,5-c)pyrimidine compounds (I), such as 2-chlorosulfonyl-5-ethoxy-7-fluoro[1,2,4]triazolo-[1,5-c]pyrimidine, that are useful for the preparation of 5-alkoxy[1,2,4]-triazolo[1,5-c]pyrimidine-2-sulfonamide herbicides, were prepared in an improved manner from 5-alkoxy[1,2,4]triazolo[1,5-c]pyrimidine-2(3H)-thione compounds, such as 5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2(3H)-thione, by oxidation with hydrogen peroxide to obtain novel 2,2'-dithio-bis(5-alkoxy[1,2,4]triazolo[1,5-c]pyrimidine) compounds, such as 2,2'-dithiobis(5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine), and subsequent chloroxidation of these intermediate compounds.(FR) Cette invention se rapporte à des composés 2-chlorosulfonyle-5-alcoxy(1,2,4)-triazolo(1,5-c)pyrimidine (I), tels que 2-chlorosulfonyle-5-éthoxy-7-fluoro[1,2,4]triazolo-(1,5-c)pyrimidine, qui sont utiles dans la préparation d'herbicides à base de 5-alcoxy[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide, et qui sont préparés selon un mode amélioré à partir de composés 5-alcoxy[1,2,4]triazolo[1,5-c]pyrimidine-2(3H)-thione, tels que 5-éthoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2(3H)-thione par oxydation avec du peroxy d'hydrogène, pour produire de nouveaux composés 2,2'-dithiobis(5-alcoxy[1,2,4]triazolo[1,5-c]pyrimidine) tels que 2,2'-dithiobis(5-éthoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine, et par chloro-oxydation ultérieure de ces composés intermédiaires.

  这些 compound (I) 是 2-氯砜基-5-羟基[1,2,4]吡咯[1,5-c]吡imidazole（如 2-氯砜基-5-乙氧-7-氟[1,2,4]吡咯-[1,5-c]吡imidazole），它们对于合成 5-羟基[1,2,4]吡咯[1,5-c]吡imidazole-2-砜基草药品是十分有用的。这些化合物是通过改进的方法，从 5-羟基[1,2,4]吡咯[1,5-c]吡imidazole-2（3H）硫化物（如 5-乙氧-7-氟[1,2,4]吡咯-[1,5-c]吡imidazole-2（3H）硫化物）氧化得到的，这样就得到了新型的 2,2'-二硫基（5-羟基[1,2,4]吡咯[1,5-c]吡imidazole）化合物（如 2,2'-二硫基（5-乙氧-7-氟[1,2,4]吡咯-[1,5-c]吡imidazole）），随后对这些中间化合物进行氯氧化。
• [EN] 2-ALKOXY-4-HYDRAZINOPYRIMIDINE COMPOUNDS AND THEIR USE IN THE PREPARATION OF 5-ALKOXY-1,2-4-TRIAZOLO[4,3-C]PYRIMIDINE-3(2H)-THIONE COMPOUNDS<br/>[FR] COMPOSES 2-ALCOXY-4-HYDRAZINOPYRIMIDINE ET LEUR UTILISATION DANS LA PREPARATION DE COMPOSES 5-ALCOXY-1,2,4-TRIAZOLO[4,3-C]PYRIMIDINE-3(2H)-THIONE
  申请人：DOWELANCO

  公开号：WO1995012597A1

  公开（公告）日：1995-05-11

  (EN) 5-Alkoxy-1,2,4-triazolo[4,3-c]pyrimidine-3(2H)-thione compounds (I), such as 5-ethoxy-8-fluoro-1,2-,4-triazolo[4,3-c]pyrimidine-3(2H)-thione, were prepared by cyclization of 2-alkoxy-4-hydrazinopyrimidine compounds (II), such as 2-ethoxy-5-fluoro-4-hydrazinopyrimidine, with carbon disulfide and hydrogen peroxide. The reaction can be carried out in the presence of a trialkylamine, such as triethylamine, in which case a trialkylammonium salt is obtained. The products are useful intermediates in the preparation of 5-alkoxy(1,2,4)triazolo(1,5-c)pyrimidine-2-sulfonamide herbicides.(FR) Cette invention se rapporte à des composés 5-alcoxy-1,2,4-triazolo[4,3-c]pyrimidine-3(2H)-thione (I), tels que 5-éthoxy-8-fluoro-1,2,4-triazolo[4,3-c]pyrimidine-3(2H)-thione, qui sont préparés par cyclisation de composés 2-alcoxy-4-hydrazinopyrimidine (II), tels que 2-éthoxy-5-fluoro-4-hydrazinopyrimidine, avec du disulphure de carbone et du peroxyde d'hydrogène. La réaction peut être effectuée en présence d'un trialkylamine, tel que du triéthylamine, auquel cas un sel trialkylammonium est obtenu. Ces produits sont utiles comme intermédiaires dans la préparation d'herbicides à base de 5-alcoxy(1,2,4)triazolo(1,5-c)pyrimidine-2-sulfonamide.

  以下是一种将英文文本翻译成中文的方案： **英文原文：** (EN) 5-Alkoxy-1,2,4-triazolo[4,3-c]pyrimidine-3(2H)-thione compounds (I), such as 5-ethoxy-8-fluoro-1,2-,4-triazolo[4,3-c]pyrimidine-3(2H)-thione, were prepared by cyclization of 2-alkoxy-4-hydrazinopyrimidine compounds (II), such as 2-ethoxy-5-fluoro-4-hydrazinopyrimidine, with carbon disulfide and hydrogen peroxide. The reaction can be carried out in the presence of a trialkylamine, such as triethylamine, in which case a trialkylammonium salt is obtained. The products are useful intermediates in the preparation of 5-alkoxy(1,2,4)triazolo(1,5-c)pyrimidine-2-sulfonamide herbicides. **中文翻译：** (FR) 这种发明涉及 5- 羟基 -1,2,4- 三聚物 [4,3-c] 垂环甲来自基 -3(2H)-硫基化合物 (I)，例如 5- 羟乙酯 -8- 氟基 -1,2-,4- 三聚物 [4,3-c] 垂环甲来自基 -3(2H)-硫基，后者通过环合 2- 羟基 -4- 级胺基嘧啶 (II)，例如 2- 羟基 -5- 氟基 -4- 级胺基嘧啶，与碳二硫化物和过氧化氢一起合成。反应可在三乙醇胺等三乙醇胺存在下进行，此时可得三乙醇胺盐。这类产物在 5- 羟基 (1,2,4) 三聚物 [1,5-c] 垂环甲来自基 -2- 磷基除草剂中具有有用中间体作用。
• 5-ALKOXY 1,2,4]TRIAZOLO 1,5-C]PYRIMIDINE-2(3H)-THIONE COMPOUNDS AND THEIR USE IN THE PREPARATION OF 2,2'-DITHIOBIS(5-ALKOXY 1,2,4]TRIAZOLO 1,5-C]-PYRIMIDINE) AND 2-CHLOROSULFONYL-5-ALKOXY 1,2,4]TRIAZOLO 1,5-C]PYRIMIDINE COMPOUNDS
  申请人：DOWELANCO

  公开号：EP0678092A1

  公开（公告）日：1995-10-25
• 5-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE-2(3H)-THIONE COMPOUNDS AND THEIR USE IN THE PREPARATION OF 2,2'-DITHIOBIS(5-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE) AND 2-CHLOROSULFONYL-5-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE COMPOUNDS
  申请人：Dow AgroSciences LLC

  公开号：EP0678092B1

  公开（公告）日：2000-01-05
• 5-ALKOXY-1,2,4-TRIAZOLO[4,3-C]PYRIMIDINE-3(2H)-THIONE COMPOUNDS AND THEIR USE IN THE PREPARATION OF 5-ALKOXY-1,2,4-TRIAZOLO[1,5-C]PYRIMIDINE-2(3H)-THIONE AND 3-HYDROCARBYLTHIO-5-ALKOXY-1,2,4-TRIAZOLO[4,3-C]PYRIMIDINE COMPOUNDS
  申请人：Dow AgroSciences LLC

  公开号：EP0678093B1

  公开（公告）日：2000-01-05