N-(4-bromo-3-(trifluoromethyl)phenyl)-N'-(4-(4-(6-methoxyquinolinyl)oxyl)phenyl)urea | 1220892-58-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(4-bromo-3-(trifluoromethyl)phenyl)-N'-(4-(4-(6-methoxyquinolinyl)oxyl)phenyl)urea
• 英文别名: N-(4-bromo-3-(trifluoromethyl)phenyl)-N'-(4-((6-methoxyquinolin-4-yl)oxy)phenyl)urea；1-[4-Bromo-3-(trifluoromethyl)phenyl]-3-[4-(6-methoxyquinolin-4-yl)oxyphenyl]urea
• CAS: 1220892-58-9
• 化学式: C₂₄H₁₇BrF₃N₃O₃
• 分子量: 532.316
• InChiKey: SHHIHFFSRPIFAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  72.5
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Heterocyclic Substituted Acardite Derivate and Application Thereof
  申请人：Zhang Aihua

  公开号：US20120053192A1

  公开（公告）日：2012-03-01

  This present invention discloses a heterocyclic substituted acardite derivate and application thereof, namely compounds in the general formula (1) or the general formula (2) or pharmaceutically acceptable salts thereof, wherein A is monosubstituted or polysubstituted quinoline, isoquinoline, quinazoline, pyrrole or pyrimidine, and the substituent is halogen, C 1-5 alkyl, C 1-5 haloalkyl, C 1-5 alkoxy, C 1-5 haloalkoxy, C 1-5 alkylamino, C 1-5 haloalkylamino, amino or nitryl; R 1 is C 1-5 alkyl; R 2 is one or more selected from hydrogen, halogen, alkyl, alkoxy, haloalkyl or haloalkoxy; and R 3 is one or more selected from hydrogen, halogen, alkyl, alkoxy, haloalkyl or haloalkoxy. The compound of the present invention and the pharmaceutically acceptable salt thereof can be used for treating tumor or leukemia.

  本发明公开了一种杂环取代阿卡尔地衍生物及其应用，即通式（1）或通式（2）中的化合物或其药学上可接受的盐，其中A是单取代或多取代的喹啉、异喹啉、喹啉、吡咯或嘧啶，取代基是卤素、C1-5烷基、C1-5卤代烷基、C1-5烷氧基、C1-5卤代烷氧基、C1-5烷基氨基、C1-5卤代烷基氨基、氨基或硝基；R1是C1-5烷基；R2是氢、卤素、烷基、烷氧基、卤代烷基或卤代烷氧基中的一个或多个；R3是氢、卤素、烷基、烷氧基、卤代烷基或卤代烷氧基中的一个或多个。本发明的化合物及其药学上可接受的盐可用于治疗肿瘤或白血病。
• HETEROCYCLIC SUBSTITUTED ACARDITE DERIVATES AND USE THEREOF
  申请人：Jiangsu Provincial Institute Of Materia Medica Co.

  公开号：EP2428506A1

  公开（公告）日：2012-03-14

  The present invention discloses a heterocyclic substituted acardite derivate and application thereof, namely compounds of the general formula (1) or the general formula (2) or pharmaceutically acceptable salts thereof, wherein A is monosubstituted or polysubstituted quinoline, isoquinoline, quinazoline, pyrrole or pyrimidine, and the substituent is halogen, C1-5alkyl, C1-5haloalkyl, C1-5alkoxy, C1-5haloalkoxy, C1-5alkylamino, C1-5haloalkylamino, amino or nitryl; R1 is C1-5alkyl; R2 is one or more selected from hydrogen, halogen, alkyl, alkoxy, haloalkyl or haloalkoxy; and R3 is one or more selected from hydrogen, halogen, alkyl, alkoxy, haloalkyl or haloalkoxy. The compound of the present invention and the pharmaceutically acceptable salt thereof can be used for treating tumor or leukemia.

  本发明公开了一种杂环取代的乌头衍生物及其应用，即通式（1）或通式（2）的化合物或其药学上可接受的盐、其中 A 是单取代或多取代的喹啉、异喹啉、喹唑啉、吡咯或嘧啶，取代基是卤素、C1-5 烷基、C1-5 卤代烷基、C1-5 烷氧基、C1-5 卤代烷氧基、C1-5 烷基氨基、C1-5 卤代烷基氨基、氨基或硝基；R1 是 C1-5 烷基；R2 是选自氢、卤素、烷基、烷氧基、卤代烷基或卤代烷氧基的一个或多个；以及 R3 是选自氢、卤素、烷基、烷氧基、卤代烷基或卤代烷氧基的一个或多个。本发明的化合物及其药学上可接受的盐可用于治疗肿瘤或白血病。
• US8957087B2
  申请人：——

  公开号：US8957087B2

  公开（公告）日：2015-02-17