trans-4-<(trifluoroacetamido)methyl>cyclohexanecarboxylic acid | 127946-34-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: trans-4-<(trifluoroacetamido)methyl>cyclohexanecarboxylic acid
• 英文别名: trans-4-{[(trifluoroacetyl)amino]methyl}cyclohexanecarboxylic acid；trans-4-[(trifluoroacetamido)methyl]cyclohexanecarboxylic acid
• CAS: 127946-34-3
• 化学式: C₁₀H₁₄F₃NO₃
• 分子量: 253.221
• InChiKey: BVNRKPGWSLRVJK-LJGSYFOKSA-N

物化性质

• 沸点：
  376.8±42.0 °C(Predicted)
• 密度：
  1.297±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.56
• 重原子数：
  17.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  66.4
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  trans-4-<(trifluoroacetamido)methyl>cyclohexanecarboxylic acid 在 氨 、 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.17h， 生成 4-N-{6-{{[4-(aminomethyl)-trans-cyclohexyl]carbonyl}amino}hexyl}cytidine 5'-tetralithium triphosphate
  参考文献：
  名称：

  Synthesis of 3′-Sugar- and Base-Modified Nucleotides and Their Application as Potent Chain Terminators in DNA Sequencing

  摘要：

  Two 3'-modified and three base-modified ddNTPs were synthesized and tested with several DNA polymerases for incorporation activity. Starting from 3'-azido-3'-deoxythymidine (AZT; 1), we were able to produce 3'-deoxy-3'-isocyanato-thymidine and 3'-deoxy-3'-isothiocyanatothymidine (3 and 4, resp,) in a rapid synthesis based on the solid-support approach (Scheme 1). These 3'-functionalities could be used to attach a spacer molecule via urea and thiourea groups, respectively. Since the thus-obtained tethered nucleotides 7 and 8 can be used to label with fluorescent dyes (cf. Scheme 5), they are convenient building blocks for practical applications in DNA sequencing. Furthermore, we synthesized, via 14 (Scheme 2), 17 (Scheme 3), and 19 (Scheme 4), the N-4-modified dideoxycytidine 5'-triphosphate dye derivatives 22, 23, and 24, respectively, with different lengths of linkers between the base residue and the dye (Scheme). Base-specific termination for the derivatives 22 and 23 was demonstrated (Fig. 2a and 2b).

  DOI：

  10.1002/(sici)1522-2675(19990908)82:9<1311::aid-hlca1311>3.0.co;2-z
• 作为产物：
  描述：

  tranexamic acid 、 三氟乙酸酐 以 二氯甲烷 为溶剂， 反应 24.0h， 以65.6%的产率得到trans-4-<(trifluoroacetamido)methyl>cyclohexanecarboxylic acid
  参考文献：
  名称：

  8-环烷基-1,3-二丙基黄嘌呤作为腺苷受体拮抗剂的构效关系。

  摘要：

  8-取代的黄嘌呤目前代表最有效的腺苷-受体拮抗剂。制备了一系列8-取代的1，3-二丙基黄嘌呤，并确定了它们分别作为人血小板和大鼠脂肪细胞的A1和A2腺苷受体拮抗剂的效力。没有研究药物能像A1腺苷受体拮抗剂那样与8-环戊基-1,3-二丙基黄嘌呤一样有效，但是8-（2-甲基环丙基）-1,3-二丙基黄嘌呤比A1腺苷受体的效力至少强1000倍。 A1比A2的腺苷受体高。虽然8-环烷基部分上的大多数取代都导致抑制A1和A2腺苷受体，8- [反式-4-（乙酰氨基甲基）环己基] -1的效力降低，

  DOI：

  10.1021/jm00169a012

文献信息

• External preparation for skin containing a depigmentation agent
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0585130A2

  公开（公告）日：1994-03-02

  An external preparation for skin including one or more than two types of tranexamic acid derivatives represented by the following general formula (A). GENERAL FORMULA (A) (In the formula (A), R₁, R₂ and R₃ represents hydrogen atoms or substituents and at least one of these is the substituent.) The external preparation for skin including the derivatives have excellent depigmentation effect as well as skin care effect.

  一种皮肤外用制剂，包括一种或两种以上由以下通式(A)代表的氨甲环酸衍生物。 通式（A） (式(A)中，R₁、R₂和 R₃ 代表氢原子或取代基，且其中至少有一个是取代基)。包括这些衍生物在内的皮肤外用制剂具有极佳的祛斑效果和护肤效果。
• US5690914A
  申请人：——

  公开号：US5690914A

  公开（公告）日：1997-11-25