methyl 2'-(2-bromo-1,1-dimethoxyethyl)-5'-methyl-5-phenyl-[2,4']bis-oxazolyl-4-carboxylate | 1064765-09-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: methyl 2'-(2-bromo-1,1-dimethoxyethyl)-5'-methyl-5-phenyl-[2,4']bis-oxazolyl-4-carboxylate
• CAS: 1064765-09-8
• 化学式: C₁₉H₁₉BrN₂O₆
• 分子量: 451.274
• InChiKey: KHIOXFVCLWCGIQ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  methyl 2'-(2-bromo-1,1-dimethoxyethyl)-5'-methyl-5-phenyl-[2,4']bis-oxazolyl-4-carboxylate 在 lithium hydroxide 、 水 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Synthesis and Antitumor Activity of Mechercharmycin A Analogues

  摘要：

  Several analogues of the cytotoxic thiopeptide IB-01211 or mechercharmycin A (1) have been synthesized. The cytotoxicity of 1 and the synthesized analogues were evaluated against a panel of three human tumor cell lines. Thiopeptide 1 and the most active derivatives 2 and 3c were chosen for further studies on effects on cell cycle progression and induction of apoptosis. Interestingly, the inhibition of cell division and activation of a programmed cell death by apoptosis were detected.

  DOI：

  10.1021/jm800513w
• 作为产物：
  描述：

  在 吡啶 、 四氯化碳 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 为溶剂， 反应 48.0h， 生成 methyl 2'-(2-bromo-1,1-dimethoxyethyl)-5'-methyl-5-phenyl-[2,4']bis-oxazolyl-4-carboxylate
  参考文献：
  名称：

  Synthesis and Antitumor Activity of Mechercharmycin A Analogues

  摘要：

  Several analogues of the cytotoxic thiopeptide IB-01211 or mechercharmycin A (1) have been synthesized. The cytotoxicity of 1 and the synthesized analogues were evaluated against a panel of three human tumor cell lines. Thiopeptide 1 and the most active derivatives 2 and 3c were chosen for further studies on effects on cell cycle progression and induction of apoptosis. Interestingly, the inhibition of cell division and activation of a programmed cell death by apoptosis were detected.

  DOI：

  10.1021/jm800513w