4-(3-carbomethoxypropyl)imidazole | 99282-58-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(3-carbomethoxypropyl)imidazole
• 英文别名: 4-(1(3)H-imidazol-4-yl)-butyric acid methyl ester；4-(1(3)H-Imidazol-4-yl)-buttersaeure-methylester；1H-Imidazole-5-butanoic acid methyl ester；methyl 4-(1H-imidazol-5-yl)butanoate
• CAS: 99282-58-3
• 化学式: C₈H₁₂N₂O₂
• 分子量: 168.195
• InChiKey: BUOSLCODVPKNHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(3-carbomethoxypropyl)imidazole 、 2-(4-氯苯基)-N-羟基乙脒 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以19%的产率得到3-(4-Chloro-benzyl)-5-[3-(1H-imidazol-4-yl)-propyl]-[1,2,4]oxadiazole
  参考文献：
  名称：

  Novel 1, 2, 4-oxadiazoles as potent and selective histamine H3 receptor antagonists

  摘要：

  Replacement of the isothiourea moiety of known histamine H-3 antagonists by certain 5-membered heteroaromatic systems can give compounds with an improved activity profile. One of these, 3-[(4-chlorophenyl)methyl]-5-[2-(1H-imidazol-4-yl)ethyl] 1,2,4-oxadiazole (GR175737) is a potent, selective, orally active and centally penetrating H-3 antagonist. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00122-9
• 作为产物：
  描述：

  5-氧代戊酸甲酯 在 氨 作用下， 以 乙醇 、 苯 为溶剂， 反应 20.42h， 生成 4-(3-carbomethoxypropyl)imidazole
  参考文献：
  名称：

  Horne, David A.; Yakushijin, Kenichi; Buechi, George, Heterocycles, 1994, vol. 39, # 1, p. 139 - 154

  摘要：

  DOI：

文献信息

• 1,(3,)5-SUBSTITUTED IMIDAZOLES, THEIR USE IN THE TREATMENT OF HYPERTENSION AND METHODS FOR THEIR PREPARATION
  申请人：Matsoukas John

  公开号：US20100166837A1

  公开（公告）日：2010-07-01

  The present invention provides novel 1,5 and 1,3,5-substituted imidazole compounds in hydrophilic or lipophilic form, which are useful as angiotensin II ATI receptor antagonists suitable for transdermal delivery. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing compounds and their use in methods of treating hypertension and cardiovascular diseases.

  本发明提供了新颖的1,5和1,3,5-取代咪唑化合物，其以亲水或亲脂形式存在，可用作适合经皮途径给药的血管紧张素II ATI受体拮抗剂。该发明还提供了含有这些化合物的药物组合物，用于制备化合物的方法和中间体，以及它们在治疗高血压和心血管疾病的方法中的应用。
• Imidazole Catalysis. V. The Intramolecular Participation of the Imidazolyl Group in the Hydrolysis of Some Esters and the Amide of γ-(4-Imidazolyl)-butyric Acid and 4-(2'-Acetoxyethyl)-imidazole²
  作者：Thomas C. Bruice、Julian M. Sturtevant

  DOI：10.1021/ja01520a062

  日期：1959.6
• Horne David A., Yakushijin Kenichi, Buechi George, Heterocycles, 39 (1994) N 1, S 139-153
  作者：Horne David A., Yakushijin Kenichi, Buechi George

  DOI：——

  日期：——
• Novel 1, 2, 4-oxadiazoles as potent and selective histamine H3 receptor antagonists
  作者：J.W. Clitherow、P. Beswick、W.J. Irving、D.I.C. Scopes、J.C. Barnes、J. Clapham、J.D. Brown、D.J. Evans、A.G. Hayes

  DOI：10.1016/0960-894x(96)00122-9

  日期：1996.4

  Replacement of the isothiourea moiety of known histamine H-3 antagonists by certain 5-membered heteroaromatic systems can give compounds with an improved activity profile. One of these, 3-[(4-chlorophenyl)methyl]-5-[2-(1H-imidazol-4-yl)ethyl] 1,2,4-oxadiazole (GR175737) is a potent, selective, orally active and centally penetrating H-3 antagonist. Copyright (C) 1996 Elsevier Science Ltd
• Horne, David A.; Yakushijin, Kenichi; Buechi, George, Heterocycles, 1994, vol. 39, # 1, p. 139 - 154
  作者：Horne, David A.、Yakushijin, Kenichi、Buechi, George

  DOI：——

  日期：——