| 865724-43-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 865724-43-2
• 化学式: C₃₀H₄₈N₄O₇
• 分子量: 576.734
• InChiKey: IEVBIBMFJUGFAV-RQNOJGIXSA-N

反应信息

• 作为反应物：
  描述：

  N-羟基丁二酰亚胺 、 在 吡啶 、 三氟乙酸酐 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以73%的产率得到
  参考文献：
  名称：

  In Situ Formation of N-Trifluoroacetoxy Succinimide (TFA-NHS): One-Pot Formation of Succinimidyl Esters, N-Trifluoroacetyl Amino Acid Succinimidyl Esters, and N-Maleoyl Amino Acid Succinimidyl Esters

  摘要：

  A method for the in situ formation of N-trifluoroacetoxy succinimide (TFA-NHS) and its application in the formation of succinimidyl esters is presented. The developed method provides N-trifluoroacetyl and N-maleoyl amino acid succinimidyl esters from a variety of amino acids using a one-pot, high-yielding protocol. Investigations into the formation of an N-maleoyl amino acid succinimidyl ester supported the proposal of a revised reaction mechanism, and contributed to the optimization of the reaction conditions.

  DOI：

  10.1021/jo201686e