(2E,8E)-undeca-2,8,10-trienoic acid | 112459-64-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2E,8E)-undeca-2,8,10-trienoic acid
• CAS: 112459-64-0
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: FTOYEHDTDKFJSE-SCPMJEMWSA-N

物化性质

• 沸点：
  321.4±21.0 °C(Predicted)
• 密度：
  0.963±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.93
• 重原子数：
  13.0
• 可旋转键数：
  7.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  37.3
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (2E,8E)-undeca-2,8,10-trienoic acid 在 正丁基锂 、 草酰氯 、 二甲基氯化铝 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 为溶剂， 反应 21.17h， 生成 (4S)-3-((4'S,5'S,6'R)-bicyclo<4.4.0>decene-4'-carbonyl)-4-(1-methylethyl)-2-oxazolidinone
  参考文献：
  名称：

  Asymmetric Diels-Alder cycloaddition reactions with chiral .alpha.,.beta.-unsaturated N-acyloxazolidinones

  摘要：

  DOI：

  10.1021/ja00212a037
• 作为产物：
  描述：

  (E)-6,8-nonadienol 在 草酰氯 、 水 、 二甲基亚砜 、 sodium hydroxide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 17.0h， 生成 (2E,8E)-undeca-2,8,10-trienoic acid
  参考文献：
  名称：

  一种新颖的基于萘烷的FKBP51选择性配体双环支架。

  摘要：

  对FKBP51的选择性抑制已成为对诸如重度抑郁症，肥胖症，慢性疼痛和某些癌症等疾病的可能新疗法。当前的FKBP51抑制剂相当大，柔韧性，并且必须进一步优化。通过使用基于结构的刚性化策略，我们在此报告FKBP51配体的新型有前途的双环支架的设计和合成。结构活性分析表明，十氢化萘支架是FBKP51选择性选择性亚口袋的最佳部分。所得化合物保留了对FKBP51的高效力，并且与紧密同源的FKBP52相比具有出色的选择性。在这个新系列的高级配体的共晶体结构中，我们展示了十氢化萘如何以典型的FKBP51选择性结合构象锁定配体的关键选择性诱导环己基部分。最好的化合物29在HeLa衍生的KB细胞系中产生细胞死亡，Hela衍生的KB细胞系是宫颈腺癌的细胞模型，其中FKBP51高度表达。我们的结果表明，在保持FKBP51选择性的同时，如何可以使FKBP51抑制剂刚性化和扩展。此类抑制剂可能是治疗FKBP51失调的人类癌症的新型工具。

  DOI：

  10.1021/acs.jmedchem.9b01157

文献信息

• EVANS, D. A.;CHAPMAN, K. T.;BISAHA, J., J. AMER. CHEM. SOC., 110,(1988) N 4, 1238-1256
  作者：EVANS, D. A.、CHAPMAN, K. T.、BISAHA, J.

  DOI：——

  日期：——
• METHOD OF ANALYZING VARIOUS SURFACE CHEMISTRIES FOR CULTURING A GIVEN CELL LINE
  申请人：Short Robert

  公开号：US20090075322A1

  公开（公告）日：2009-03-19

  In one embodiment of the invention, there is provided a method of analyzing various surface chemistries for culturing a particular cell line, which includes the steps of: (1) providing a plasma polymerized surface having first and second regions, the first region including a first concentration of carboxylic acid groups in the plasma polymerized surface and the second region including a second concentration of carboxylic acid groups in the plasma polymerized surface, wherein the first and second concentrations are different; (2) culturing cells from the cell line on the plasma polymerized surface in each the region; (3) observing activity of the cultured cells in each the region; and (4) analyzing the activity of the cultured cells in each region.
• KIT INCLUDING SUBSTRATES WITH VARIOUS SURFACE CHEMISTRIES
  申请人：Short Robert

  公开号：US20130023003A1

  公开（公告）日：2013-01-24

  In one embodiment of the invention, there is provided a kit including: (i) a plasma polymerized surface having first and second regions, said first region including a first concentration of carboxylic acid groups on said plasma polymerized surface and said second region including a second concentration of carboxylic acid groups on said plasma polymerized surface, wherein said first concentration and said second concentration are different; (ii) a first plasma polymerized secondary substrate having carboxylic acid groups disposed consistently thereacross at a concentration equal to said first concentration; and, (iii) a second plasma polymerized secondary substrate having carboxylic acid groups disposed consistently thereacross at a concentration equal to said second concentration.
• METHOD OF SELECTING A SURFACE CHEMISTRY FOR CULTURING A GIVEN CELL LINE
  申请人：Corning Incorporated

  公开号：US20130309654A1

  公开（公告）日：2013-11-21

  In one embodiment of the invention, there is provided a method of selecting a surface chemistry for culturing a given cell line, including the steps of: (i) providing a first substrate having a plasma polymerized surface with first and second regions, said first region having a first concentration of carboxylic acid groups on said plasma polymerized surface and said second region having a second concentration of carboxylic acid groups on said plasma polymerized surface, wherein said first and second concentrations are different; (ii) culturing cells from said cell line on said plasma polymerized surface in each said region; (iii) observing activity of said cultured cells in each said region, said activity selected from the group consisting of alkaline phosphatase activity of the cultured cells, cell growth of the cultured cells, attachment of the cultured cells, and cell spreading of the cultured cells; and iv) selecting, based on a particular observed activity, a secondary substrate for culturing said cells wherein the secondary substrate has a plasma polymerized surface having a constant concentration of carboxylic acid groups thereon which is equal to the concentration of carboxylic acid groups in the region on said first substrate wherein the cells exhibit said particular observed activity.
• US8288118B2
  申请人：——

  公开号：US8288118B2

  公开（公告）日：2012-10-16