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4-羟基-DL-色氨酸 | 16533-77-0

中文名称
4-羟基-DL-色氨酸
中文别名
4-羟基色氨酸
英文名称
4-hydroxytryptophan
英文别名
2-amino-3-(4-hydroxy-1H-indol-3-yl)propanoic acid
4-羟基-DL-色氨酸化学式
CAS
16533-77-0
化学式
C11H12N2O3
mdl
——
分子量
220.228
InChiKey
QSHLMQDRPXXYEE-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    520.6±50.0 °C(Predicted)
  • 密度:
    1.484±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    -1.5
  • 重原子数:
    16
  • 可旋转键数:
    3
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.18
  • 拓扑面积:
    99.3
  • 氢给体数:
    4
  • 氢受体数:
    4

安全信息

  • 海关编码:
    2933990090

反应信息

  • 作为产物:
    描述:
    Boc-4-hydroxy-L-tryptophan 在 1,2-乙二硫醇三氟乙酸 作用下, 以 二氯甲烷 为溶剂, 反应 4.0h, 以55%的产率得到4-羟基-DL-色氨酸
    参考文献:
    名称:
    18 F-标记的氟乙氧基色氨酸类似物作为潜在的PET肿瘤显像剂的合成与生物学评价
    摘要:
    作为我们对基于色氨酸的放射性示踪剂进行正电子发射断层成像(PET)进行肿瘤成像研究的继续,我们合成了三种新的氟乙氧基色氨酸类似物,并在体内进行了评估。这些新的示踪剂(即,4-(2- [ 18 F]氟乙氧基) - DL -色氨酸([ 18 F] -4- FEHTP),6-(2- [ 18 F]氟乙氧基) - DL -色氨酸([ 18 ˚F ] -6- FEHTP)和7-(2- [ 18 F]氟乙氧基) - DL -色氨酸([ 18F] 7-FEHTP)在吲哚核的4-,6-或7-位带有氟乙氧基侧链。参考化合物和前体通过多步法合成。放射性合成是通过间接方法(用[ 18 F]氟乙基甲苯磺酸酯对相应的羟基色氨酸进行O-烷基化)或直接方法(使用受保护的甲磺酰基前体进行的亲核性[ 18 F]氟化)完成的,方法是在不添加载体的情况下进行亲核18 F氟化)。两种方法的放射化学产率(校正后的衰变)在10%至1
    DOI:
    10.1021/mp500312t
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文献信息

  • NOVEL COMPOSITIONS OF MATTER AND PHARMACEUTICAL COMPOSITIONS
    申请人:PSILERA INC.
    公开号:US20210346347A1
    公开(公告)日:2021-11-11
    Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.
    新型吲哚化合物和哌哗甲酸盐类药物的制剂被生产,提供在新型口服、经皮和鼻用制药组合物中,用于治疗神经系统、情绪或滥用疾病和障碍。
  • PESTICIDAL COMPOSITION COMPRISING INDOLE DERIVATES
    申请人:Bednarek Pawel
    公开号:US20090028796A1
    公开(公告)日:2009-01-29
    The present invention is directed to pesticidal compositions comprising indole derivatives. These indole derivatives are especially active against phytopathogenic fungi. Furthermore, the invention relates to the use of indole derivatives for the production of pesticides and the use of the compositions according to the invention as pesticides. The present invention is also directed to a process for producing a pesticidal composition and to pesticidal compositions prepared by this process. In addition, the invention relates to a process for preventing or combating pests and to a process for protecting plants against pests, especially against phytopathogenic fungi. Further, the invention is directed to plants or seeds as well as objects or materials which have been protected against pests by treatment with a composition according to the invention. Further, the invention is directed to a method for identifying a substance having pesticidal activity. Further, the invention is directed to a method of identifying the mode of action of and/or of providing binding proteins for a pesticidal compound of the present invention. Finally, the invention is directed to a method for diagnosing pest infection of a plant and to the use of a pesticidal compound of the present invention as diagnostic markers.
    本发明涉及包含吲哚衍生物的杀虫组合物。这些吲哚衍生物特别对植物病原真菌具有活性。此外,本发明涉及使用吲哚衍生物制备杀虫剂以及使用本发明中的组合物作为杀虫剂。本发明还涉及制备杀虫组合物的过程以及通过该过程制备的杀虫组合物。此外,本发明还涉及预防或对抗害虫的过程以及保护植物免受害虫,特别是植物病原真菌的过程。此外,本发明还涉及经过本发明中的组合物处理后受到保护的植物或种子以及物体或材料。本发明还涉及识别具有杀虫活性的物质的方法。此外,本发明还涉及识别本发明中杀虫化合物的作用方式和/或提供结合蛋白的方法。最后,本发明涉及诊断植物害虫感染的方法以及使用本发明中的杀虫化合物作为诊断标记的方法。
  • C-DI-GMP BINDING PEPTIDES
    申请人:Universität Basel
    公开号:EP3335720A1
    公开(公告)日:2018-06-20
    The present invention is directed to a peptide comprising at least one amino acid sequence (I), wherein said amino acid sequence (I) comprises, preferably consists of, the amino sequence D1-X2-X3-X4-X5-X6-X7-X8-X9-Y10-X11-G12-X13-R14-R15-R16-X17-X18-D19, a composition and a pharmaceutical composition comprising the peptide of the invention, the peptide of the invention for use as a medicament in the treatment or prevention of a disease, non-medical use of the peptide of the invention, and a nucleic acid encoding the peptide of the invention.
    本发明涉及一种包含至少一个氨基酸序列(I)的多肽,其中所述氨基酸序列(I)包含,优选由氨基酸序列D1-X2-X3-X4-X5-X6-X7-X8-X9-Y10-X11-G12-X13-R14-R15-R16-X17-X18-D19组成、包含本发明多肽的组合物和药物组合物,本发明多肽用作治疗或预防疾病的药物,本发明多肽的非医疗用途,以及编码本发明多肽的核酸。
  • Use of compounds that are able to increase the serum IGF-1 level for the preparation of a therapeutical composition for treatment of various disease states associated with a reduced IGF-1 serum level in humans and animals
    申请人:VEIJLEN N.V.
    公开号:US10716778B2
    公开(公告)日:2020-07-21
    The present disclosure relates to the use of one or more compounds that are capable of increasing the serum level of insulin-like growth factor 1 (IGF-1) for the preparation of a therapeutical composition, in particular, in the form of a food supplement, for the treatment of subjects suffering from serious fatigue and exhausting symptoms, burn-out and chronic fatigue syndrome. The same composition can also be used by patients suffering from depression, Alzheimer disease, irritated bowel syndrome, osteoporosis, type 2 diabetes, or for anti-aging, immune therapy and recovery after exercise. The composition also has a use in veterinary applications for increasing the growth and immunity in animals.
    本公开涉及一种或多种能够提高血清中胰岛素样生长因子1(IGF-1)水平的化合物用于制备治疗组合物,特别是以食品补充剂的形式,用于治疗患有严重疲劳和疲惫症状、倦怠和慢性疲劳综合征的患者。同样的组合物还可用于抑郁症、老年痴呆症、肠易激综合征、骨质疏松症、2 型糖尿病患者,或用于抗衰老、免疫疗法和运动后恢复。该成分还可用于兽医领域,提高动物的生长速度和免疫力。
  • Processes for the production of tryptamines
    申请人:New Atlas Biotechnologies LLC
    公开号:US11136293B2
    公开(公告)日:2021-10-05
    Disclosed herein are prokaryotic and eukaryotic microbes, including E. coli and S. cerevisiae, genetically altered to biosynthesize tryptamine and tryptamine derivatives. The microbes of the disclosure may be engineered to contain plasmids and stable gene integrations containing sufficient genetic information for conversion of an anthranilate or an indole to a tryptamine. The fermentative production of substituted tryptamines in a whole-cell biocatalyst may be useful for cost effective production of these compounds for therapeutic use.
    本文公开了经基因改造可生物合成色胺和色胺衍生物的原核和真核微生物,包括大肠杆菌和酿酒葡萄球菌。本发明公开的微生物可被设计成含有质粒和稳定的基因整合,其中包含将蒽酸或吲哚转化为色胺的足够遗传信息。在全细胞生物催化剂中发酵生产取代的色胺可能有助于以具有成本效益的方式生产这些用于治疗的化合物。
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