4-羟基-N,N-二异丙基色胺 | 132328-45-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 4-羟基-N,N-二异丙基色胺
• 英文名称: 4-hydroxy-N,N-diisopropyltryptamine
• 英文别名: 4-hydroxydiisopropyltryptamine；3-[2-[di(propan-2-yl)amino]ethyl]-1H-indol-4-ol
• CAS: 132328-45-1
• 化学式: C₁₆H₂₄N₂O
• mdl: MFCD04972059
• 分子量: 260.379
• InChiKey: KBRYKXCBGISXQV-UHFFFAOYSA-N

物化性质

• 沸点：
  424.9±35.0 °C(Predicted)
• 密度：
  1.084±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  39.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  4-羟基-N,N-二异丙基色胺 在 吡啶 、 盐酸 作用下， 以 1,4-二氧六环 、 乙醚 为溶剂， 反应 2.25h， 生成 N,N-diisopropyltryptamine-4-glutarate hydrochloride salt
  参考文献：
  名称：

  WO2023/108260

  摘要：

  公开号：
• 作为产物：
  描述：

  N-(2-(4-(benzyloxy)-1H-indol-3-yl)ethyl)-N-isopropylpropan-2-amine 在 palladium on activated charcoal 、 氢气 作用下， 生成 4-羟基-N,N-二异丙基色胺
  参考文献：
  名称：

  WO2023/108260

  摘要：

  公开号：

文献信息

• TRYPTAMINE PRODRUGS
  申请人：Field Trip Psychedelics Inc.

  公开号：US20210403425A1

  公开（公告）日：2021-12-30

  The present invention provides a tryptamine prodrug compound. A compound represented by the formula (I) where each symbol is as described in the specification, or a salt or zwitterion thereof, is converted to an active which has 5HT2A receptor agonist activity, and is useful as an agent for the treatment of depression.

  本发明提供了一种色胺前药化合物。化合物由公式(I)表示，其中每个符号如说明书中所述，或其盐或离子，被转化为具有5HT2A受体激动剂活性的活性物质，并用作抗抑郁剂的药物。
• PESTICIDAL COMPOSITION COMPRISING INDOLE DERIVATES
  申请人：Bednarek Pawel

  公开号：US20090028796A1

  公开（公告）日：2009-01-29

  The present invention is directed to pesticidal compositions comprising indole derivatives. These indole derivatives are especially active against phytopathogenic fungi. Furthermore, the invention relates to the use of indole derivatives for the production of pesticides and the use of the compositions according to the invention as pesticides. The present invention is also directed to a process for producing a pesticidal composition and to pesticidal compositions prepared by this process. In addition, the invention relates to a process for preventing or combating pests and to a process for protecting plants against pests, especially against phytopathogenic fungi. Further, the invention is directed to plants or seeds as well as objects or materials which have been protected against pests by treatment with a composition according to the invention. Further, the invention is directed to a method for identifying a substance having pesticidal activity. Further, the invention is directed to a method of identifying the mode of action of and/or of providing binding proteins for a pesticidal compound of the present invention. Finally, the invention is directed to a method for diagnosing pest infection of a plant and to the use of a pesticidal compound of the present invention as diagnostic markers.

  本发明涉及包含吲哚衍生物的杀虫组合物。这些吲哚衍生物特别对植物病原真菌具有活性。此外，本发明涉及使用吲哚衍生物制备杀虫剂以及使用本发明中的组合物作为杀虫剂。本发明还涉及制备杀虫组合物的过程以及通过该过程制备的杀虫组合物。此外，本发明还涉及预防或对抗害虫的过程以及保护植物免受害虫，特别是植物病原真菌的过程。此外，本发明还涉及经过本发明中的组合物处理后受到保护的植物或种子以及物体或材料。本发明还涉及识别具有杀虫活性的物质的方法。此外，本发明还涉及识别本发明中杀虫化合物的作用方式和/或提供结合蛋白的方法。最后，本发明涉及诊断植物害虫感染的方法以及使用本发明中的杀虫化合物作为诊断标记的方法。
• Methods of treating food allergy conditions
  申请人：Palo Alto Investors LP

  公开号：US11045454B2

  公开（公告）日：2021-06-29

  Methods for treating a subject for a food allergy condition are provided. Aspects of the methods include administering to a subject in need thereof a psychedelic agent in a manner effective to treat the subject for a food allergy condition. Effective administration of a psychedelic agent may include administering the psychedelic agent in an amount effective to treat the subject for the food allergy condition. In some instances, the subject is known to have a food allergy condition.

  本文提供了治疗食物过敏症的方法。这些方法的各个方面包括以有效治疗食物过敏症的方式向有需要的受试者施用迷幻剂。有效施用迷幻剂可包括以有效治疗受试者食物过敏症的量施用迷幻剂。在某些情况下，受试者已知患有食物过敏症。
• Processes for the production of tryptamines
  申请人：New Atlas Biotechnologies LLC

  公开号：US11136293B2

  公开（公告）日：2021-10-05

  Disclosed herein are prokaryotic and eukaryotic microbes, including E. coli and S. cerevisiae, genetically altered to biosynthesize tryptamine and tryptamine derivatives. The microbes of the disclosure may be engineered to contain plasmids and stable gene integrations containing sufficient genetic information for conversion of an anthranilate or an indole to a tryptamine. The fermentative production of substituted tryptamines in a whole-cell biocatalyst may be useful for cost effective production of these compounds for therapeutic use.

  本文公开了经基因改造可生物合成色胺和色胺衍生物的原核和真核微生物，包括大肠杆菌和酿酒葡萄球菌。本发明公开的微生物可被设计成含有质粒和稳定的基因整合，其中包含将蒽酸或吲哚转化为色胺的足够遗传信息。在全细胞生物催化剂中发酵生产取代的色胺可能有助于以具有成本效益的方式生产这些用于治疗的化合物。
• Tryptamine prodrugs
  申请人：Field Trip Psychedelics Inc.

  公开号：US11292765B2

  公开（公告）日：2022-04-05

  The present invention provides a tryptamine prodrug compound. A compound represented by the formula (I) where each symbol is as described in the specification, or a salt or zwitterion thereof, is converted to an active which has 5HT2A receptor agonist activity, and is useful as an agent for the treatment of depression.

  本发明提供了一种色胺原药化合物。 由式（I）（其中各符号如说明书所述）代表的化合物或其盐或齐聚物转化为具有 5HT2A 受体激动剂活性的活性物质，可用作治疗抑郁症的药物。