2-((pyridin-4-yl)methylamino)-4-methylpentanoic acid hydrochloride | 1394816-63-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-((pyridin-4-yl)methylamino)-4-methylpentanoic acid hydrochloride
• 英文别名: N-(4-pyridylmethyl)-L-leucine hydrochloride
• CAS: 1394816-63-7
• 化学式: C₁₂H₁₈N₂O₂*ClH
• 分子量: 258.748
• InChiKey: GLOQDJGTPGTORR-MERQFXBCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.09
• 重原子数：
  17.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  62.22
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-((pyridin-4-yl)methylamino)-4-methylpentanoic acid hydrochloride 、 cadmium(II) acetate dihydrate 以 水 为溶剂， 反应 0.17h， 以65%的产率得到
  参考文献：
  名称：

  Variable Water Adsorption in Amino Acid Derivative Based Homochiral Metal Organic Frameworks

  摘要：

  Six new Cd-containing homochiral metal organic framework materials [{Cd(L1)(C1)}(H2O)](infinity), (1a), [Cd(L1)(Br)](infinity) (1b), [Cd(L2)(Cl)](H2O)](infinity), (2a), [{Cd-2(L2)(2)(Br)(2)}(H2O)(3)](infinity), (2b) [{Cd(L3)(Cl)}(H2O)(2)](infinity) (3a), and [(Cd(L3)(Br)}(H2O)(2)](infinity) (3b) [L1 = 24(PYridin-4-yl)methylamino)-4-methylpentanoic acid], [L2 = 2-(pyridin-4-yl)methylamino)-3-hydroxypropanoic acid], and [L3 = 2((pyridin-4-yl)methylamino)-3-hydroxybutanoic acid] have been synthesized using pyridine functionalized amino acid (L-leucine, L-serine, and L-threonine) homochiral links and Cd(CH3COO)(2)center dot 2H(2)O and characterized via single crystal Xray diffraction (XRD), powder X-ray diffraction (PXRD), variable temperature powder X-ray diffraction (VTPXRD), thermogravimetric analysis and water adsorption experiments. Side chains in different amino acid derivatives and anions (Cl-, Br-) have been identified to play an important role in structural diversity (from porous to nonporous) as well as physical properties. These metal organic frameworks (MOFs) exhibit a distinct water adsorption nature and capacity, e.g., high adsorption at low partial pressure based on architectural diversities.

  DOI：

  10.1021/cg3008443
• 作为产物：
  描述：

  4-吡啶甲醛 、 L-亮氨酸 在 sodium carbonate 、 sodium tetrahydroborate 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 4.0h， 以70%的产率得到2-((pyridin-4-yl)methylamino)-4-methylpentanoic acid hydrochloride
  参考文献：
  名称：

  Variable Water Adsorption in Amino Acid Derivative Based Homochiral Metal Organic Frameworks

  摘要：

  Six new Cd-containing homochiral metal organic framework materials [{Cd(L1)(C1)}(H2O)](infinity), (1a), [Cd(L1)(Br)](infinity) (1b), [Cd(L2)(Cl)](H2O)](infinity), (2a), [{Cd-2(L2)(2)(Br)(2)}(H2O)(3)](infinity), (2b) [{Cd(L3)(Cl)}(H2O)(2)](infinity) (3a), and [(Cd(L3)(Br)}(H2O)(2)](infinity) (3b) [L1 = 24(PYridin-4-yl)methylamino)-4-methylpentanoic acid], [L2 = 2-(pyridin-4-yl)methylamino)-3-hydroxypropanoic acid], and [L3 = 2((pyridin-4-yl)methylamino)-3-hydroxybutanoic acid] have been synthesized using pyridine functionalized amino acid (L-leucine, L-serine, and L-threonine) homochiral links and Cd(CH3COO)(2)center dot 2H(2)O and characterized via single crystal Xray diffraction (XRD), powder X-ray diffraction (PXRD), variable temperature powder X-ray diffraction (VTPXRD), thermogravimetric analysis and water adsorption experiments. Side chains in different amino acid derivatives and anions (Cl-, Br-) have been identified to play an important role in structural diversity (from porous to nonporous) as well as physical properties. These metal organic frameworks (MOFs) exhibit a distinct water adsorption nature and capacity, e.g., high adsorption at low partial pressure based on architectural diversities.

  DOI：

  10.1021/cg3008443

文献信息

• Anions mediated amino-type Cd-MOFs catalysts for efficient photocatalytic hydrogen evolution
  作者：Jun-Feng Qian、Hua-Dong Yue、Peng-Xiang Qiu、Qian Liang、Meng-Ting Hang、Ming-Yang He、Yun-Fei Bu、Qun Chen、Zhi-Hui Zhang

  DOI：10.1016/j.jssc.2021.122632

  日期：2021.12

  photocatalytic activity for hydrogen generation in aqueous solution of Na2S/Na2SO3 upon irradiation at full light. The photocurrent time test showed that Cd-LCl showed a higher photocurrent intensity than those of Cd-LFor and Cd-LOAc, which proved the lower electron-hole recombination and correspondingly higher hydrogen production photocatalysis active. The highest H2 production rate reached 17242 ​μmol ​g−1 ​h−1

  光催化分解水可以将太阳能直接高效地转化为化学能。金属有机框架 (MOF) 材料以其高设计灵活性和金属中心功能化的优势而闻名。在本研究中，基于不同阴离子介导的吡啶基亮氨酸衍生物，通过简单的溶剂蒸发方法成功制备了一系列以 Cd 为中心的 MOF。单晶 X 射线衍射显示了三个 Cd-MOF 的同构 3D 手性配位网络，其螺旋链由相邻的羧酸根基团连接。在螺旋配位链中，甲酸根 (For) 和乙酸根 (OAc) 阴离子在 Cd-L For和 Cd-L OAc 中采用螯合模式，而氯化物在 Cd-L Cl 中用作单极配体。进行粉末 X 射线衍射 (PXRD)、热重分析、紫外-可见光谱、光电流-时间测试 (It) 和莫特-肖特基 (MS) 曲线来表征和分析这些 Cd-MOF。所有样品在全光照射下都表现出在Na 2 S/Na 2 SO 3水溶液中产氢的光催化活性。光电流时间测试表明，Cd-L Cl显示出比Cd-L