3-(2,4-dichlorophenyl)-1-(2-nitrophenyl)prop-2-en-1-one | 73749-27-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(2,4-dichlorophenyl)-1-(2-nitrophenyl)prop-2-en-1-one
• 英文别名: 1-(2-nitrophenyl)-3-(2,4-dichlorophenyl)-2propen-1-one
• CAS: 73749-27-6
• 化学式: C₁₅H₉Cl₂NO₃
• 分子量: 322.147
• InChiKey: XLPFIHWFNAXSOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  邻硝基苯乙酮 、 2,4-二氯苯甲醛 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以79.1%的产率得到3-(2,4-dichlorophenyl)-1-(2-nitrophenyl)prop-2-en-1-one
  参考文献：
  名称：

  Synthesis and antifungal activity of chalcone derivatives

  摘要：

  In the present study, using chalcone as a lead compound, a series of its derivatives (compounds 1-30) were designed and synthesised. Their activity of anti-pathogenic fungi of plants has been evaluated. It is found that these compounds have good antifungal activity against Sclerotinia sclerotiorum, Helminthosprium maydis, Botrytis cinerea, Rhizoctonia solani and Gibberella zeae. Among them, the inhibition of growth for compound 30 against S. sclerotiorum showed 89.9%, with the median effective concentrations (EC50) of 15.4gmL(-1). The inhibition of growth for compounds 28, 29 and 30 at a concentration of 100gmL(-1) against H. maydis is 90.3%, 90.7% and 91.1%, with EC50 of 15.1, 18.3 and 18.1gmL(-1), respectively.

  DOI：

  10.1080/14786419.2015.1007973

文献信息

• Process for the preparation of 1,3-disubstituted-2-azoyl-2-propen-1-ones
  申请人：Rohm and Haas Company

  公开号：US04182862A1

  公开（公告）日：1980-01-08

  This invention involves an improved process for the preparation of pesticidal 1,3-disubstituted-2-azoyl-2-propen-1-ones from the corresponding dibromoketones and azoles at a temperature from about 60.degree. C. to 180.degree. C. either neat or in the presence of an inert solvent.

  这项发明涉及一种改进的制备杀虫剂1,3-二取代-2-氮杂-2-丙烯-1-酮的方法，该方法是通过在60°C至180°C的温度下，使用相应的二溴代酮和氮杂环化合物，不需溶剂或在惰性溶剂的存在下进行。