(2S,3S,4S)-tert-butyl 2-ethyl 3-benzoyl-4-((E)-4-ethoxy-4-oxobut-2-en-1-yl)-6-methoxy-3,4-dihydro-1H-carbazole-2,9(2H)-dicarboxylate | 1360110-66-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3S,4S)-tert-butyl 2-ethyl 3-benzoyl-4-((E)-4-ethoxy-4-oxobut-2-en-1-yl)-6-methoxy-3,4-dihydro-1H-carbazole-2,9(2H)-dicarboxylate
• CAS: 1360110-66-2
• 化学式: C₃₄H₃₉NO₈
• 分子量: 589.686
• InChiKey: XZXRKELTQDZGET-NOIJSFACSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.26
• 重原子数：
  43.0
• 可旋转键数：
  9.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  110.13
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  、 乙氧甲酰基亚甲基三苯基膦 以 甲苯 为溶剂， 反应 16.0h， 生成 、 (2S,3S,4S)-tert-butyl 2-ethyl 3-benzoyl-4-((E)-4-ethoxy-4-oxobut-2-en-1-yl)-6-methoxy-3,4-dihydro-1H-carbazole-2,9(2H)-dicarboxylate
  参考文献：
  名称：

  Multicatalytic Asymmetric Synthesis of Complex Tetrahydrocarbazoles via a Diels–Alder/Benzoin Reaction Sequence

  摘要：

  Expanding upon the recently developed aminocatalytic asymmetric indole-2,3-quinodimethane strategy, a straightforward synthesis of structurally and stereochemically complex tetrahydrocarbazoles has been devised. The chemistry's complexity-generating power was further harnessed by designing a multicatalytic, one-pot Diels-Alder/benzoin reaction sequence to stereoselectively access trans-fused tetracyclic indole-based compounds having four stereogenic centers with very high fidelity.

  DOI：

  10.1021/ol300192p