N-methyl-4-{[1-methyl-2-(phenylamino)-1H-benzimidazol-5-yl]oxy}pyridine-2-carboxamide | 611215-15-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-methyl-4-{[1-methyl-2-(phenylamino)-1H-benzimidazol-5-yl]oxy}pyridine-2-carboxamide
• 英文别名: N-methyl-4-({2-[methyl(phenyl)amino]-1H-1,3-benzodiazol-5-yl}oxy)pyridine-2-carboxamide；4-(2-anilino-1-methylbenzimidazol-5-yl)oxy-N-methylpyridine-2-carboxamide
• CAS: 611215-15-7
• 化学式: C₂₁H₁₉N₅O₂
• 分子量: 373.414
• InChiKey: GLRHEOXLLKWUGI-UHFFFAOYSA-N

物化性质

• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  81.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(3-amino-4-methylamino-phenoxy)-pyridine-2-carboxylic acid methylamide 、 硫代异氰酸苯酯 在 甲醇 作用下， 反应 32.0h， 生成 N-methyl-4-{[1-methyl-2-(phenylamino)-1H-benzimidazol-5-yl]oxy}pyridine-2-carboxamide
  参考文献：
  名称：

  Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors

  摘要：

  A series of arylaminobenzimidazoles was designed and synthesized as Raf kinase inhibitors. Exploration of the structure-activity relationship resulted in compounds that are potent in vitro and show desirable in vivo properties.

  DOI：

  10.1021/jm801050k

文献信息

• Substituted benz-azoles and methods of their use as inhibitors of Raf kinase
  申请人：Amiri Payman

  公开号：US20070299039A1

  公开（公告）日：2007-12-27

  New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

  提供了新的取代苯唑化合物、组合物和抑制人或动物体内Raf激酶活性的方法。这些新化合物组合物可以单独使用，也可以与至少一种额外的药物联合使用，用于治疗Raf激酶介导的疾病，如癌症。
• SUBSTITUTED BENZ-AZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE
  申请人：Amiri Payman

  公开号：US20100196368A1

  公开（公告）日：2010-08-05

  New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

  本发明提供了新的取代苯并唑化合物、组合物和抑制人类或动物主体中Raf激酶活性的方法。新的化合物组成物可以单独使用或与至少一种其他药物联合使用，用于治疗Raf激酶介导的疾病，如癌症。
• SUBSTITUTED BENZAZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE
  申请人：Amiri Payman

  公开号：US20120288501A1

  公开（公告）日：2012-11-15

  New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

  提供了新的取代苯唑化合物、组合物和抑制人类或动物主体中Raf激酶活性的方法。这些新的化合物组合物可以单独使用或与至少一种额外的药物联合使用，用于治疗Raf激酶介导的疾病，如癌症。
• One-pot synthesis of 2-aminobenzimidazoles using 2-chloro-1,3-dimethylimidazolinium chloride (DMC)
  作者：Gerald D. Artman、Catherine F. Solovay、Christopher M. Adams、Brian Diaz、Martin Dimitroff、Takeru Ehara、Danlin Gu、Fupeng Ma、Donglei Liu、Bridget R. Miller、Teresa E. Pick、Daniel J. Poon、David Ryckman、David A. Siesel、Brady S. Stillwell、Tyson Swiftney、Jonathan P. van Dyck、Chun Zhang、Nan Ji

  DOI：10.1016/j.tetlet.2010.07.177

  日期：2010.10

  2-Chloro-1,3-dimethylimidazolinium chloride (DMC or DMC-Cl) has been found to effectively and rapidly generate 2-aminobenzimidazoles from 1,2-diaminoarenes and isothiocyanates in moderate to good yields at room temperature in a one-pot operation. (C) 2010 Elsevier Ltd. All rights reserved.
• SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS
  申请人：Novartis Vaccines and Diagnostics, Inc.

  公开号：EP1499311B1

  公开（公告）日：2009-11-04