1-Amino-3-ethylpentan-3-ol | 1369248-66-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Amino-3-ethylpentan-3-ol
• CAS: 1369248-66-7
• 化学式: C₇H₁₇NO
• mdl: MFCD21803699
• 分子量: 131.22
• InChiKey: PKKWLMYBLBBXLB-UHFFFAOYSA-N

物化性质

• 沸点：
  219.0±13.0 °C(Predicted)
• 密度：
  0.903±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] 1-(4-(ISOXAZOL-5-YL)-1H-PYRAZOL-1-YL)-2-METHYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS IL-17 AND IFN-GAMMA INHIBITORS FOR TREATING AUTOIMMUNE DISEASES AND CHRONIC INFLAMMATION<br/>[FR] DÉRIVÉS DE 1-(4-(ISOXAZOL-5-YL)-1 H-PYRAZOL-1-YL)-2-MÉTHYLPROPAN-2-OL ET COMPOSÉS APPARENTÉS EN TANT QU'INHIBITEURS D'IL-17 ET D'IFN-GAMMA POUR LE TRAITEMENT DE MALADIES AUTO-IMMUNES ET D'UNE INFLAMMATION CHRONIQUE
  申请人：IMMUNIC AG

  公开号：WO2019048541A1

  公开（公告）日：2019-03-14

  The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein Ar, Z and Y are as described herein and R1 is a group of the structure (formula (II)), wherein n is 0 or 1; R2 is H, deuterium or methyl; R3 is methyl, trilluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked *, which are suitable for the treatment of autoimmune diseases and chronic inflammation.

  本发明涉及具有通用公式（I）的化合物，以及其中Ar、Z和Y如本文所述的药用可接受盐和溶剂化物，其中R1是具有结构（公式（II））的组，其中n为0或1；R2是H，氘或甲基；R3是甲基，三氟甲基，乙基，或者与R2共同形成一个环丙基组，或者R3形成一个甲基桥接到标记为*的碳原子上，这些化合物适合用于治疗自身免疫性疾病和慢性炎症。
• Benzimidazole derivatives
  申请人：——

  公开号：US20040044056A1

  公开（公告）日：2004-03-04

  This invention relates to the compounds represented by a general formula [I]: 1 [in which A 1 and A 2 represent optionally fluorine-substituted methine or the like; B represents halogen, cyano, lower alkyl or the like; D represents optionally substituted heterocyclic group or the like; and G represents C 3 -C 20 aliphatic group such as alicyclic group]. These compounds inhibit nociceptin activities due to their high affinity to nociceptin receptor, and are useful as analgesic, antiobestic, corebral function improver, drugs for treatment of alzheimer's disease and dementia, remedies for schizophrenia and neurodegenerative diseases, antidepressant, remedies for diabetes insipidus, polyuria, hypotension and so on.

  本发明涉及由一般式[I]表示的化合物：1[其中，A1和A2表示选择性氟代甲基或类似物；B表示卤素，氰基，低碳烷基或类似物；D表示选择性取代的杂环基团或类似物；G表示C3-C20脂肪族基团，例如脂环族基团]。这些化合物由于对痛觉受体具有高亲和力而抑制了痛觉肽活性，并且可用作镇痛剂，抗肥胖剂，脑功能改善剂，治疗阿尔茨海默病和痴呆症的药物，治疗精神分裂症和神经退行性疾病的药物，抗抑郁剂，治疗尿崩症，多尿症，低血压等的药物。
• Toughened thermoplastics
  申请人：POLYSAR LIMITED

  公开号：EP0393944A2

  公开（公告）日：1990-10-24

  Functionalized thermoplastics such as styrene-maleic anhydrate copolymers polystyrene or maleated polyolefins may be toughened with halogenated rubbers which are copolymers of isoprene and isobutylene provided a dialkyl or dihydroxyalkyl amino alkanol is present as a compatibilizer. The toughened thermoplastics have about a two fold increase in IZOD impact resistance.

  功能化热塑性塑料，如苯乙烯-马来水合共聚物聚苯乙烯或马来酸化聚烯烃，可以用卤化橡胶进行增韧，卤化橡胶是异戊二烯和异丁烯的共聚物，但必须有二烷基或二羟基烷基氨基烷醇作为相容剂。增韧后的热塑性塑料的 IZOD 抗冲击性提高了约两倍。
• Method of improving the electrical conductivity of a shaped resin article and an electrostatic coating process
  申请人：DAI-ICHI KOGYO SEIYAKU CO., LTD.

  公开号：EP0732706A2

  公开（公告）日：1996-09-18

  A nitrogen-containing compound of the following general formula (1) is kneaded into a resin molding material, the kneaded mixture is molded and the surface of the resulting article is subjected to corona discharge treatment. Further, a coating material having electrostatic charges is sprayed and deposited on the article after the corona discharge treatment. This can provide a shaped resin article with remarkably improved electrical conductivity from a less electrically conductive resin, without substantially deteriorating the physical properties and the color of the article. Further, electrostatic coating excellent in coating efficiency, surface appearance, productivity or the like is possible. where R1 represents an alkyl group or alkenyl group of 5 to 21 carbon atoms, R2 represents -H or -CH3, R3 and R4 may be the same or different and each represents an alkyl group of 1 to 4 carbon atoms, A represents -(CH2)n- or and n is 1 to 5.

  将以下通式（1）的含氮化合物捏合到树脂成型材料中，然后将捏合混合物成型，并对成型物品的表面进行电晕放电处理。此外，在电晕放电处理后，在制品上喷涂和沉积具有静电荷的涂层材料。这样就可以用导电性较差的树脂制成导电性能显著提高的成型树脂制品，而不会严重影响制品的物理性能和颜色。此外，静电涂层在涂层效率、表面外观、生产率等方面也有可能得到改善。 其中 R1 代表 5 至 21 个碳原子的烷基或烯基，R2 代表-H 或-CH3，R3 和 R4 可以相同或不同，且各自代表 1 至 4 个碳原子的烷基，A 代表-(CH2)n- 或-( )n-，n 为 1 至 5。 且 n 为 1 至 5。
• BENZIMIDAZOLE DERIVATIVES
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1342717A1

  公开（公告）日：2003-09-10

  This invention relates to the compounds represented by a general formula [I]:    [in which A1 and A2 represent optionally fluorine-substituted methine or the like; B represents halogen, cyano, lower alkyl or the like; D represents optionally substituted heterocyclic group or the like; and G represents C3-C20 aliphatic group such as alicyclic group]. These compounds inhibit nociceptin activities due to their high affinity to nociceptin receptor, and are useful as analgesic, antiobestic, corebral function improver, drugs for treatment of alzheimer's disease and dementia, remedies for schizophrenia and neurodegenerative diseases, antidepressant, remedies for diabetes insipidus, polyuria, hypotension and so on.

  本发明涉及通式[I]所代表的化合物： [其中 A1 和 A2 代表任选氟取代的甲基或类似物；B 代表卤素、氰基、低级烷基或类似物；D 代表任选取代的杂环基团或类似物；G 代表 C3-C20 脂肪族基团，例如脂环族基团]。这些化合物由于与痛觉素受体的高亲和力而抑制痛觉素的活性，可用作镇痛剂、抗镇静剂、改善大脑核心功能的药物、治疗老年痴呆症和痴呆症的药物、治疗精神分裂症和神经退行性疾病的药物、抗抑郁剂、治疗糖尿病、多尿、低血压等。