6'-deoxy-6'-azido-4'-deoxy-4'-(thymin-1-yl)-2',5'-anhydro-L-mannofuranose dimethyl acetal | 900513-65-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6'-deoxy-6'-azido-4'-deoxy-4'-(thymin-1-yl)-2',5'-anhydro-L-mannofuranose dimethyl acetal
• 英文别名: 2,5-Anhydro-6-azido-4,6-dideoxy-4-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-1-(dimethyl acetal)-L-mannose；1-[(2S,3R,4R,5R)-2-(azidomethyl)-5-(dimethoxymethyl)-4-hydroxyoxolan-3-yl]-5-methylpyrimidine-2,4-dione
• CAS: 900513-65-7
• 化学式: C₁₃H₁₉N₅O₆
• 分子量: 341.324
• InChiKey: YDCDJYVMXCQQTH-AXTSPUMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  6'-deoxy-6'-azido-4'-deoxy-4'-(thymin-1-yl)-2',5'-anhydro-L-mannofuranose dimethyl acetal 在 4-甲苯硫酚 作用下， 以 甲醇 为溶剂， 生成 1-((2S,3R,4R,5R)-2-Aminomethyl-5-dimethoxymethyl-4-hydroxy-tetrahydro-furan-3-yl)-5-methyl-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  One-step synthesis of novel tricyclic isomeric azidonucleosides

  摘要：

  Several tricyclic azido-isonucleosides were formed in high yields by the treatment of pyrimidine isonucleosides with triphenylphosphine, tetrabromomethane, and sodium azide. The regioselective ring opening of these tricyclic azido-isonucleosides was also investigated. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.03.034
• 作为产物：
  描述：

  2,5-anhdyro-4-deoxy-4-(thymin-1-yl)-L-mannofuranose dimethyl acetal 在 sodium azide 、 三苯基膦 作用下， 以 四氯化碳 为溶剂， 以75%的产率得到6'-deoxy-6'-azido-4'-deoxy-4'-(thymin-1-yl)-2',5'-anhydro-L-mannofuranose dimethyl acetal
  参考文献：
  名称：

  Studies on Modified Oligonucleotides

  摘要：

  DOI：

  10.1080/10426500701734539