1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-nitro-ethanol | 94371-28-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-nitro-ethanol
• 英文别名: 1-(2,2-Dimethyl-1,3-dioxolan-4-yl)-2-nitroethanol
• CAS: 94371-28-5
• 化学式: C₇H₁₃NO₅
• 分子量: 191.184
• InChiKey: NUMMXFZHBMAYKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  84.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] PROCESS FOR PREPARING AMINOTETRAHYDROPYRANS<br/>[FR] PROCÉDÉ DE PRÉPARATION D'AMINOTÉTRAHYDROPYRANES
  申请人：F I S - FABBRICA ITALIANA SINTETICI S P A

  公开号：WO2017093209A1

  公开（公告）日：2017-06-08

  The present invention relates to a process for preparing 3-amino tetrahydropyrans and, more particularly, to an improved method for synthesizing a 2,3,5-substituted tetrahydropyran derivative, intermediate being used in the preparation of dipeptidyl peptidase-IV enzyme inhibitors (DPP-4 inhibitors).

  本发明涉及一种制备3-氨基四氢吡喃的方法，更具体地说，涉及一种改进的合成2,3,5-取代四氢吡喃衍生物的方法，该衍生物是用于制备二肽基肽酶IV酶抑制剂（DPP-4抑制剂）的中间体。
• Process for preparing aminotetrahydropyrans
  申请人：F.I.S.—Fabbrica Italiana Sintetici S.p.A.

  公开号：US10377732B2

  公开（公告）日：2019-08-13

  The present invention relates to a process for preparing 3-amino tetrahydropyrans and, more particularly, to an improved method for synthesizing a 2,3,5-substituted tetrahydropyran derivative, intermediate being used in the preparation of dipeptidyl peptidase-IV enzyme inhibitors (DPP-4 inhibitors).

  本发明涉及一种制备3-氨基四氢吡喃的工艺，更具体地说，涉及一种合成2,3,5-取代的四氢吡喃衍生物的改进方法，该衍生物中间体可用于制备二肽基肽酶-IV酶抑制剂（DPP-4抑制剂）。
• PROCESS FOR PREPARING AMINOTETRAHYDROPYRANS
  申请人：F.I.S.- Fabbrica Italiana Sintetici S.p.A.

  公开号：EP3271344A1

  公开（公告）日：2018-01-24
• Process For Preparing Aminotetrahydropyrans
  申请人：F.I.S. - Fabbrica Italiana Sintetici S.p.A.

  公开号：US20180290995A1

  公开（公告）日：2018-10-11

  The present invention relates to a process for preparing 3-amino tetrahydropyrans and, more particularly, to an improved method for synthesizing a 2,3,5-substituted tetrahydropyran derivative, intermediate being used in the preparation of dipeptidyl peptidase-IV enzyme inhibitors (DPP-4 inhibitors).