(2R,3R,4S,5R,6R)-2-[[1-(1-adamantyl)triazol-4-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol | 1190202-92-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4S,5R,6R)-2-[[1-(1-adamantyl)triazol-4-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 1190202-92-6
• 化学式: C₁₉H₂₉N₃O₆
• 分子量: 395.456
• InChiKey: YMTIZUWZNWSOJS-OKZQXTEUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  叠氮金刚烷 、 1-propynyl-β-D-galactopyranoside 在 copper diacetate 、 铜 作用下， 以 水 、 叔丁醇 为溶剂， 反应 24.0h， 以85%的产率得到(2R,3R,4S,5R,6R)-2-[[1-(1-adamantyl)triazol-4-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
  参考文献：
  名称：

  Expanding the application scope of glycosidases using click chemistry

  摘要：

  Glycosidase-mediated glycosylation of alkynyl alcohols and azide-containing alcohols was followed by a click reaction, affording various types of triazole glycosides. The activities of triazole glycosides detected in Subsequent bioassays show that this procedure is a feasible approach to the development of anti-fungal drugs. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.11.044

文献信息

• Expanding the application scope of glycosidases using click chemistry
  作者：Wen-Ya Lu、Xing-Wen Sun、Chen Zhu、Jian-He Xu、Guo-Qiang Lin

  DOI：10.1016/j.tet.2009.11.044

  日期：2010.1

  Glycosidase-mediated glycosylation of alkynyl alcohols and azide-containing alcohols was followed by a click reaction, affording various types of triazole glycosides. The activities of triazole glycosides detected in Subsequent bioassays show that this procedure is a feasible approach to the development of anti-fungal drugs. (C) 2009 Elsevier Ltd. All rights reserved.