2-(3-Chlorophenyl)-6-methoxychromen-4-one | 70354-23-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(3-Chlorophenyl)-6-methoxychromen-4-one
• CAS: 70354-23-3
• 化学式: C₁₆H₁₁ClO₃
• 分子量: 286.715
• InChiKey: AATYEDAGGOUNGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.12
• 重原子数：
  20.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  39.44
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  盐酸胍 、 2-(3-Chlorophenyl)-6-methoxychromen-4-one 在 potassium hydroxide 作用下， 以 甲醇 为溶剂， 以70%的产率得到4-(2-hydroxy-5-methoxyphenyl)-6-(3-chlorophenyl)-2-aminopyrimidine
  参考文献：
  名称：

  Assessment of antiplatelet activity of 2-aminopyrimidines

  摘要：

  A series of 4,6-diaryl-2-aminopyrimidines was developed as antiplatelet agents and their potency was evaluated by in vitro assay. Compound 14k was found to be two times more potent than aspirin. These encouraging results could be helpful for the development of new antiplatelet compounds. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.01.035
• 作为产物：
  描述：

  3-氯苯甲酸 在 吡啶 、 硫酸 、 溶剂黄146 、 potassium hydroxide 、 三氯氧磷 作用下， 以 吡啶 为溶剂， 反应 5.0h， 生成 2-(3-Chlorophenyl)-6-methoxychromen-4-one
  参考文献：
  名称：

  Synthesis of novel 4,6-diaryl-2-aminopyrimidines as potential antiplasmodial agents

  摘要：

  A novel series of 4,6-diaryl-2-aminopyrimidines 8a-o has been synthesized and evaluated for in vitro antiplasmodial activity against Plasmodium falciparum. Out of the 15 compounds synthesized and tested, 6 compounds have shown IC50 values in the range of 1.61-9.53 mu g/mL. These compounds are several times more potent than chloroquine and quinine, the two standard drugs used for the purpose of comparison.

  DOI：

  10.1007/s00044-012-0328-z