1-(diethoxyphosphoryl)-2-ethoxy-2-oxo-1,2-λ⁵-azaphospholane | 1224865-99-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物
• 英文名称: 1-(diethoxyphosphoryl)-2-ethoxy-2-oxo-1,2-λ⁵-azaphospholane
• 英文别名: 2-ethoxy-1-diethoxyphpsphoryl-2-oxo-1,2(λ5)-azaphospholane；1-Diethoxyphosphoryl-2-ethoxy-1,2lambda5-azaphospholidine 2-oxide；1-diethoxyphosphoryl-2-ethoxy-1,2λ5-azaphospholidine 2-oxide
• CAS: 1224865-99-9
• 化学式: C₉H₂₁NO₅P₂
• 分子量: 285.217
• InChiKey: RPNJZLQKQPRHBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  65.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  uranyl nirate hexahydrate 、 1-(diethoxyphosphoryl)-2-ethoxy-2-oxo-1,2-λ⁵-azaphospholane 以 乙醇 为溶剂， 以63%的产率得到[UO2(2-ethoxy-1-diethoxyphosphoryl-2-oxo-1,2(λ5)-azaphospholane)(NO3)2]
  参考文献：
  名称：

  Uranium complexes of cyclic O,O-bidentate ligands with the P–N–P backbone

  摘要：

  The formation of uranium complexes of novel ligands belonging to phosphorylated 2-oxo-1,2-azaphospholane series, namely 2-ethoxy-1-diethoxyphosphoryl-2-oxo-1,2 lambda(5)-azaphospholane (1a) and both individual R*,R*- and R*,S*-diastereomers of the related 2-oxo-2-phenyl-1,2 lambda(5)-azaphospholanes 1b,c with different surrounding at the exocyclic phosphorus atom, has been studied. The structures of the complexes of ML composition obtained in the reaction with uranyl nitrate in 1:1 ratio were found to depend on the difference in donor properties of the oxygen atom of endo- and exocyclic phosphoryl groups. The ligand 1a possessing the greater difference, serves as O-monodentate one with metal-oxygen bonding via the endocyclic P=O function while both isomers of 1b, c coordinate to uranyl cation in a O,O-bidentate fashion. In solutions the ML complexes reacted with air oxygen to afford (mu(2)-peroxo)-bridged uranium complexes [{UO2(L)NO3}(2)(mu(2)-O-2)] which structures were confirmed by X-ray crystallography data. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.04.007
• 作为产物：
  描述：

  Diethoxy-(2-ethoxy-2-oxidoazaphospholidin-2-ium-1-yl)phosphane 在 双氧水 作用下， 以 叔丁醇 为溶剂， 生成 1-(diethoxyphosphoryl)-2-ethoxy-2-oxo-1,2-λ⁵-azaphospholane
  参考文献：
  名称：

  N-Phosphoryl-2-oxo-1,2-azaphospholanes: First Example of Cyclic O,O-Bidentate Ligands with the P-N-P Backbone

  摘要：

  A convenient one-pot synthesis of N-phosphoryl-2-oxo-1,2-azaphospholanes was developed starting from commercially available or simple-to-prepare phosphorus (III) acid chlorides and 3-bromopropylamine. The compounds readily form complexes with f-elements of ML, ML2, and M2L3 composition including (mu 2-peroxo)-bridged uranium complexes, depending on both the ligand and metal nature.

  DOI：

  10.1080/10426507.2010.499549

文献信息

• Facile One-Pot Synthesis and X-ray Characterization of N-(Thio)phosphoryl-2-oxo-1,2-azaphospholanes: First Example of Cyclic O,O- and O,S-Bidentate Ligands with the P-N-P Backbone
  作者：Irina Odinets、Inga Aladzheva、Olga Bykhovskaya、Yulya Nelyubina、Alexander Korlyukov、Pavel Petrovskii

  DOI：10.1055/s-0029-1218600

  日期：2010.2

  A convenient one-pot synthesis of N-phosphoryl- and N-thiophosphoryl-2-oxo-1,2-azaphospholanes was developed, starting from commercially available or simple-to-prepare phosphorus(III) acid chlorides and (3-bromopropyl)amine hydrobromide. The method is based on the intramolecular Arbuzov reaction of bis-phosphorus(III)-substituted N-(3-bromopropyl)amines generated in turn by double phosphorylation of

  的一种方便的一锅合成Ñ -phosphoryl-和Ñ -thiophosphoryl -2-氧代-1,2- azaphospholanes被开发，从可商购的或简单到制备磷（III）酰氯和起始（3-溴丙基）氢溴酸胺。该方法基于双磷（III）取代的N-（3-溴丙基）胺的分子内Arbuzov反应，依次通过（3-溴丙基）胺的双重磷酸化生成，然后氧化或将硫添加到环状磷中（三）种形成。 磷（III）烷基化-闭环-杂环-1,2-氮杂膦酸酯-非对映异构体