美他氯铵 | 100-95-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 美他氯铵
• 中文别名: 酰胺苄胺
• 英文名称: benzyl-(dodecylcarbamoyl-methyl)-dimethyl-ammonium; chloride
• 英文别名: benzyl[2-(dodecylamino)-2-oxoethyl]dimethylammonium chloride；(benzyl)(dodecylaminocarbonylmethyl)-di(methyl)-ammonium chloride；2-[benzyl(dimethyl)azaniumyl]-N-dodecylethanimidate;hydrochloride
• CAS: 100-95-8
• 化学式: C₂₃H₄₁N₂O*Cl
• 分子量: 397.044
• InChiKey: COLOBWZNRYGBRU-UHFFFAOYSA-N

物化性质

• 熔点：
  147-148°

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  27
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  6.1(b)
• 海关编码：
  2924299090
• 包装等级：
  III
• 危险类别：
  6.1(b)
• 危险品运输编号：
  UN 2811

反应信息

• 作为产物：
  描述：

  lauryl Ν,Ν-dimethylaminoacetamide 、 氯化苄 生成 美他氯铵
  参考文献：
  名称：

  DE763310

  摘要：

  公开号：

文献信息

• Nitric Oxide Releasing Prodrugs of Therapeutic Agents
  申请人：SATYAM Apparao

  公开号：US20110263526A1

  公开（公告）日：2011-10-27

  The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.

  本发明涉及已知药物或治疗剂的一氧化氮释放前药，其在此处表示为式(I)的化合物，其中药物或治疗剂包含一个或多个功能基团，独立地选自羧酸、氨基、羟基和巯基。该发明还涉及制备一氧化氮释放前药（式(I)的化合物）的方法，含有它们的药物组合物以及使用这些前药的方法。
• GAMMA-AAPEPTIDES WITH POTENT AND BROAD-SPECTRUM ANTIMICROBIAL ACTIVITY
  申请人：Cai Jianfeng

  公开号：US20150274782A1

  公开（公告）日：2015-10-01

  The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

  本发明涉及一种新型类别的抗微生物药物，称为γ-AA肽。当前发明提供了各种类别的γ-AA肽，例如线性γ-AA肽、环状γ-AA肽和脂质化γ-AA肽。本发明的γ-AA肽被设计为具有抗微生物活性，同时稳定且无毒。γ-AA肽似乎也不会导致被治疗微生物体内微生物产生抗药性。因此，所披露的γ-AA肽可用于治疗与病原微生物相关的各种医疗状况。
• γ-AApeptides with potent and broad-spectrum antimicrobial activity
  申请人：Cai Jianfeng

  公开号：US10144764B2

  公开（公告）日：2018-12-04

  The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

  本发明涉及一类名为γ-AA肽的新型抗菌剂。本发明提供了各种类型的 γ-AA肽，例如线性γ-AA肽、环状γ-AA肽和脂化γ-AA肽。本发明中的γ-AA 肽具有抗菌活性，同时稳定无毒。γ-AA肽似乎也不会导致被处理微生物产生抗药性。因此，所公开的γ-AA 肽可用于治疗与病原微生物有关的各种病症。
• Gamma-AApeptides with potent and broad-spectrum antimicrobial activity
  申请人：Cai Jianfeng

  公开号：US10308686B2

  公开（公告）日：2019-06-04

  The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

  本发明涉及一类名为γ-AA肽的新型抗菌剂。本发明提供了各种类型的 γ-AA肽，例如线性γ-AA肽、环状γ-AA肽和脂化γ-AA肽。本发明中的γ-AA 肽具有抗菌活性，同时稳定无毒。γ-AA肽似乎也不会导致被处理微生物产生抗药性。因此，所公开的γ-AA 肽可用于治疗与病原微生物有关的各种病症。
• Diastolic recoil method and device for treatment of cardiac pathologies
  申请人：Criscione John C.

  公开号：US10398556B2

  公开（公告）日：2019-09-03

  The present invention provides methods and direct cardiac contact diastolic recoil device to improve diastolic recoil of a heart and includes a biocompatible film attached to or enclosing one or more structural elements that store elastic energy during heart contraction and release energy during heart filling.

  本发明提供了改善心脏舒张回缩的方法和直接心脏接触舒张回缩装置，包括附着或包围一个或多个结构元件的生物相容性薄膜，这些元件在心脏收缩时储存弹性能量，并在心脏充盈时释放能量。