3,5-diethyl-1,2,4-thiadiazole | 1613161-21-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3,5-diethyl-1,2,4-thiadiazole
• CAS: 1613161-21-9
• 化学式: C₆H₁₀N₂S
• 分子量: 142.225
• InChiKey: QERSKHJQSDBZGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  硫代丙酰胺 在 硫酸 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 以68 %的产率得到3,5-diethyl-1,2,4-thiadiazole
  参考文献：
  名称：

  电化学烯胺酮-硫代酰胺环化和硫代酰胺二聚环化用于噻唑和 1,2,4-噻二唑的可调合成

  摘要：

  开发了一种在无金属和氧化剂条件下烯胺酮与硫代酰胺的绿色可持续电化学氧化环化反应，为噻唑合成提供了一种有效的方法。此外，在不存在烯胺酮的情况下，可以通过硫代酰胺的电化学二聚来选择性地获得1,2,4-噻二唑。

  DOI：

  10.1021/acs.orglett.4c01532

文献信息

• NOVEL HETEROAROMATIC DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
  申请人：Boléa Christelle

  公开号：US20100144756A1

  公开（公告）日：2010-06-10

  The present invention relates to novel compounds of Formula (I), wherein X 1 , X 2 , X 3 , X 4 , Y 1 , Y 2 , Y 3 , Y 4 , M 1 , M 2 , M 3 , A m and B n are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—subtype 4 (“mGluR4”) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.

  本发明涉及式（I）的新化合物，其中X1、X2、X3、X4、Y1、Y2、Y3、Y4、M1、M2、M3、Am和Bn如式（I）中所定义；该发明化合物是代谢型谷氨酸受体亚型4（“mGluR4”）的调节剂，对于治疗或预防中枢神经系统疾病以及其他受mGluR4受体调节的疾病具有用处。 该发明还涉及制药组合物以及利用这些化合物制造药物的用途，以及利用这些化合物预防和治疗mGluR4参与的疾病的用途。
• Facile access to 3,5-symmetrically disubstituted 1,2,4-thiadiazoles through phosphovanadomolybdic acid catalyzed aerobic oxidative dimerization of primary thioamides
  作者：Kazuhisa Yajima、Kazuya Yamaguchi、Noritaka Mizuno

  DOI：10.1039/c4cc02313g

  日期：——

  In the presence of Keggin-type phosphovanadomolybdic acids, e.g., H6PV3Mo9O40, oxidative dimerization of various kinds of primary thioamides including aromatic, heterocyclic, and aliphatic ones efficiently proceeded to give the corresponding 3,5-disubstituted 1,2,4-thiadiazoles in excellent yields.

  在Keggin型磷酸钒钼酸（例如H6PV3Mo9O40）的存在下，各种伯硫代酰胺（包括芳族，杂环和脂肪族）的氧化二聚反应可有效地进行，从而以优异的质量得到相应的3,5-二取代的1,2,4-噻二唑产量。
• Substituted Diazabicycloalkane Derivates
  申请人：Frost Jennifer M.

  公开号：US20080275048A1

  公开（公告）日：2008-11-06

  Compounds of formula (I) Z-Ar 1 —Ar 2 (I) wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

  化合物的公式为（I）Z-Ar1—Ar2（I），其中Z是一种二氮杂双环胺，Ar1是一种5或6成员芳香环，而Ar2则选自未取代或取代的5或6成员杂芳基环；未取代或取代的双环杂芳基环；3,4-（亚甲氧基）苯基；咔唑基；四氢咔唑基；萘基；和苯基；其中苯基在间位或对位上取代有0、1、2或3个取代基。这些化合物在治疗由α7 nAChR配体预防或改善的疾病或疾病方面是有用的。此外，还披露了包含公式（I）化合物的制药组合物以及使用这些化合物和组合物的方法。
• BIARYL SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES
  申请人：Ji Jianguo

  公开号：US20110124676A1

  公开（公告）日：2011-05-26

  The invention relates to biaryl substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

  本发明涉及取代双芳基氮杂环烷烃衍生物、包含该类化合物的组合物以及使用该类化合物和组合物治疗疾病和疾病的方法。
• ANTIBACTERIAL AGENTS
  申请人：BROWN David Ryall

  公开号：US20120122918A1

  公开（公告）日：2012-05-17

  Compounds of formula (1) have antibacterial activity: wherein R represents hydrogen or 1, 2 or 3 optional substituents; W is ═C(R 1 )—; R 1 is hydrogen and R 2 is hydrogen, methyl, or fluorine; or R 1 and R 2 taken together are —CH 2 —, —CH 2 CH 2 , —O—, or, in either orientation, —O—CH 2 — or —OCH 2 CH 2 —; and R 3 is a radical of formula -(Alk 1 ) m -(Z) p -(Alk 2 )-Q.

  式（1）的化合物具有抗菌活性：其中R代表氢或1、2或3个可选取代基；W为═C（R1）—；R1为氢，R2为氢、甲基或氟；或R1和R2组合为—CH2—、— —、—O—，或者以任何方向为—O— —或—O —；R3是式-(Alk1)m-(Z)p-(Alk2)-Q的基团。