retronecine N-oxide | 6870-33-3

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: retronecine N-oxide
• 英文别名: (1R,8R)-7-(hydroxymethyl)-4-oxido-2,3,5,8-tetrahydro-1H-pyrrolizin-4-ium-1-ol
• CAS: 6870-33-3；55869-55-1
• 化学式: C₈H₁₃NO₃
• 分子量: 171.196
• InChiKey: VUMAFSXBFDKENO-ZAZKALAHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  58.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  倒千里光裂碱 在 乙醇 、 水 、 双氧水 作用下， 生成 retronecine N-oxide
  参考文献：
  名称：

  Culvenor; Smith, Australian Journal of Chemistry, 1957, vol. 10, p. 464,470

  摘要：

  DOI：

文献信息

• 109. The senecio alkaloids. Part II. Isatinecine
  作者：Ernest C. Leisegang、Frank L. Warren

  DOI：10.1039/jr9490000486

  日期：——
• COMPOUNDS FOR THE TREATMENT OF FLAVIVIRAL INFECTIONS
  申请人：De Moor Olivier

  公开号：US20110195929A1

  公开（公告）日：2011-08-11

  Described are various compounds and methods for the treatment of flaviviral infections. In particular, alkaloids and imino sugars in arabinose and/or lyxose stereochemical configuration with antiflaviviral activity are described.
• TREATMENT OF LYSOSOMAL STORAGE DISORDERS AND OTHER PROTEOSTATIC DISEASES
  申请人：De Moor Olivier

  公开号：US20110237538A1

  公开（公告）日：2011-09-29

  Described are various compounds, in particular iminosugars, and methods for the treatment of proteostatic diseases, in particular lysosomal storage disorders. The compound may be a pharmacoperone of an enzyme selected from: (a) Acid alpha-glucosidase; (b) Acid beta-glucosidase; (c) glucocerebrosidase; (d) alpha-Galactosidase A; (e) Acid beta-galactosidase; (f) beta-Hexosaminidase A; (g) beta-Hexosaminidase B; (h) Acid sphingomyelinase; (i) Galactocerebrosidase; (j) Acid ceramidase; (k) Arylsulfatase A; (l) alpha-L-Iduronidase; (m) Iduronate-2-sulfatase; (n) Heparan N-sulfatase; (o) alpha-N-Acetylglucosaminidase; (p) Acetyl-CoA: alpha-glucosaminide N-acetyltransferase; (q) N-Acetylglucosamine-6-sulfate sulfatase; (r) N-Acetylgalactosamine-6-sulfate sulfatase; (s) Acid beta-galactosidase; (t) Arylsulfatase B; (u) beta-Glucuronidase; (v) Acid alpha-mannosidase; (w) Acid beta-mannosidase; (x) Acid alpha-L-fucosidase; (y) Sialidase; and (z) alpha-N-acetylgalactosaminidase.
• [EN] ANTIINFECTIVE COMPOUNDS<br/>[FR] COMPOSÉS ANTI-INFECTIEUX
  申请人：SUMMIT CORP PLC

  公开号：WO2010029313A1

  公开（公告）日：2010-03-18

  Described are various compounds and methods for the treatment of infections. In particular, alkaloids and imino sugars with antiviral activity are described, including those with activity against HCV and RSV.
• de Waal, Onderstepoort journal of veterinary science and animal industry, 1940, vol. 14, p. 433,441
  作者：de Waal

  DOI：——

  日期：——

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