1-(β-D-arabinofuranosyl)thymine | 897953-53-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(β-D-arabinofuranosyl)thymine
• 英文别名: ara-T；1-[(2S,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-5-methylpyrimidine-2,4-dione
• CAS: 897953-53-6
• 化学式: C₁₀H₁₄N₂O₇
• 分子量: 274.23
• InChiKey: UQKDXTGUIZUQOD-JAKMQLQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  D-arabinofuranose 1-O-phosphate lithium salt 、 胸腺嘧啶 在 recombinant Escherichia coli uridine phosphorylase 作用下， 以 水 为溶剂， 反应 168.0h， 以61%的产率得到1-(β-D-arabinofuranosyl)thymine
  参考文献：
  名称：

  化学合成酶法合成β-d-阿拉伯呋喃糖基嘌呤核苷

  摘要：

  使用α- d-阿拉伯呋喃糖1的9-（β- d-阿拉伯呋喃糖基）-2-氟腺嘌呤（氟达拉滨）和9-（β- d呋喃糖基）-2-氨基-6-甲氧嘌呤（去甲腺苷）的化学催化合成。描述了作为通用底物的β-磷酸酯和作为生物催化剂的重组大肠杆菌嘌呤核苷磷酸化酶（PNP）。麦克唐纳法被用来合成α - d-阿拉伯呋喃糖1-磷酸，它是与β- d-阿拉伯吡喃糖1-磷酸的混合物，从d的过酰基衍生物开始制备的。-不同异构体（异头）组成的阿拉伯糖。发现混合的磷酸盐可以成功地用于与PNP催化的嘌呤碱的反应，指出β- d-阿拉伯吡喃葡萄糖1-磷酸盐相对于PNP的惯性。2-氟腺嘌呤和α- d-呋喃糖1-磷酸的反应向氟达拉滨的方向转移，而2-氨基-6-甲氧基嘌呤的反应在约1小时达到平衡。碱和奈拉拉滨的等摩尔比。重组大肠杆菌尿苷磷酸化酶催化由胸腺嘧啶和α - d-阿拉伯呋喃糖1-磷酸合成1-（β- d-阿拉伯呋喃糖基）胸腺嘧啶（ara-T）。

  DOI：

  10.1055/s-0030-1260010

文献信息

• Methods of producing and using single-stranded deoxyribonucleic acids and compositions for use in practicing the same
  申请人：Takara Bio USA, Inc.

  公开号：US10584363B2

  公开（公告）日：2020-03-10

  Methods of producing single-stranded deoxyribonucleic acids (ssDNAs) are provided. Aspects of the methods include generating a double stranded deoxyribonucleic acid (dsDNA) and then selectively degrading one strand of the dsDNA to produce a ssDNA. ssDNAs produced using methods of the invention find use in a variety of applications, including genomic modification applications. Also provided are compositions, e.g., kits, that find use in practicing various embodiments of the invention.

  本文提供了生产单链脱氧核糖核酸（ssDNA）的方法。 这些方法的各个方面包括产生双链脱氧核糖核酸（dsDNA），然后选择性地降解dsDNA的一条链以产生ssDNA。使用本发明方法产生的ssDNA可用于各种应用，包括基因组修饰应用。 此外，还提供了可用于实施本发明各种实施方案的组合物，如试剂盒。
• Methods for detecting agglutination and compositions for use in practicing the same
  申请人：The Regents of the University of California

  公开号：US11149296B2

  公开（公告）日：2021-10-19

  Methods are provided for detecting antigen binding agents in samples. Aspects of the methods include detection of the aggregation of antigen binding agents with polynucleotide-bound antigens by sensitive proximity-based association of the antigen-bound polynucleotides. Aspects of the methods also include methods for the detection of such proximity-based association through nucleic acid amplification. In addition, compositions, e.g., reagents, kits, and devices, useful in practicing various embodiments of the methods are provided.

  提供了检测样品中抗原结合剂的方法。这些方法的各个方面包括通过与抗原结合的多核苷酸的灵敏近距离结合来检测抗原结合剂与多核苷酸结合抗原的聚集。这些方法的各个方面还包括通过核酸扩增来检测这种基于近距离结合的方法。此外，还提供了有助于实施本方法各实施例的组合物，如试剂、试剂盒和装置。
• METHODS FOR DETECTING AGGLUTINATION AND USE OF KITS IN PRACTICING THE SAME
  申请人：The Regents of the University of California

  公开号：EP3283638B1

  公开（公告）日：2022-06-08
• METHODS FOR DETECTING AGGLUTINATION AND COMPOSITIONS FOR USE IN PRACTICING THE SAME
  申请人：The Regents of the University of California

  公开号：EP3283638A1

  公开（公告）日：2018-02-21
• Light Activated Shape Memory Co-Polymers
  申请人：Tong Hung Tat

  公开号：US20080021166A1

  公开（公告）日：2008-01-24

  The present discovery uses monomers which contain reversible photo-crosslinkable groups in addition to primary polymerizable groups. The mechanical properties of these materials and the reversibility of the photo-activated shape memory effect demonstrate the effectiveness of using photo-irradiation to effect change in modulus and shape memory effect. In the preferred embodiment the reaction mixture includes a photo-reactive monomer comprising a photo reactive group and a polymerizable group; a second monomer, which is more preferably a mixture of monomers, which are acrylate based; a multi-functional crosslinking agent, preferably 1,6 hexanediol diacrylate (HDODA); an initiator, preferably a free radical initiator; and a fifth, optional, component which is a modifying polymer. The mixture of the second monomer, crosslinking agent, and initiator comprise the base polymer matrix into which the photo-reactive monomer is incorporated. The polymeriziable group of the photo reactive monomer allows the photo reactive monomer to polymerize with the base polymer matrix.