| 1574468-08-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1574468-08-8
• 化学式: CH₄O*C₅₀H₄₀Cl₂N₈O₆Zn
• 分子量: 1017.26
• InChiKey: QOFRJWLCEIBSNT-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  甲醇 、 二(2-吡啶)酮肟 、 托灭酸 、 zinc(II) chloride 在 potassium hydroxide 作用下， 以 甲醇 为溶剂， 反应 1.5h， 以55%的产率得到
  参考文献：
  名称：

  Antioxidant activity and interaction with DNA and albumins of zinc–tolfenamato complexes. Crystal structure of [Zn(tolfenamato)2(2,2′-dipyridylketoneoxime)2]

  摘要：

  The zinc(II) complex of the non-steroidal anti-inflammatory drug tolfenamic acid (=Htolf) in the presence of 2,2 '-dipyridylketone oxime (=Hpko) as a N,N'-donor heterocyclic ligand, [Zn(tolf-O)(2)(Hpko-N,N')(2)]center dot MeOH (=1 center dot MeOH), has been synthesized and characterized by physicochemical techniques including X-ray crystallography. The complex exhibits good binding affinity to human or bovine serum albumin with high binding constant values. Complex 1 and previously reported Zn-tolfenamato complexes were tested for their free radical scavenging activity and in vitro inhibitory activity against soybean lipoxygenase and exhibited significant activity with [Zn(tolf)(2)(1,10-phenantroline)] being the most active compound. The complexes interact with calf-thymus (CT) DNA via intercalation, and can displace the DNA-bound ethidium bromide with 1 exhibiting the highest binding constant to CT DNA. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.12.019