1,2,3-tri-N-phenylcarbamylglycerol | 124105-80-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2,3-tri-N-phenylcarbamylglycerol
• 英文别名: 1,2,3-tris-phenylcarbamoyloxy-propane；1,2,3-Tris-phenylcarbamoyloxy-propan；2,3-bis(phenylcarbamoyloxy)propyl N-phenylcarbamate
• CAS: 124105-80-2
• 化学式: C₂₄H₂₃N₃O₆
• 分子量: 449.463
• InChiKey: SLCBVADYFPBYGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  异氰酸苯酯 、 甘油 在 吡啶 作用下， 反应 24.0h， 生成 1,2,3-tri-N-phenylcarbamylglycerol
  参考文献：
  名称：

  合成和评估一系列新的三，二和单N烷基氨基甲酰基间苯三酚作为胆固醇酯酶的构象约束抑制剂

  摘要：

  1,3,5-三-N-烷基氨基甲酰基间苯三酚（1-4）被合成为三酰基甘油（TGs）的构象约束类似物，以探索Jenck在胆固醇酯酶抑制中的邻近效应。对于胆固醇酯酶的抑制，抑制剂1-4的效力比TG的底物类似物1,2,3-三-N - N-烷基氨基甲酰甘油（13-15）强220-760倍。三齿抑制剂的比较1-4，二齿抑制剂3,5-二- ñ - ñ -alkylcarbamyloxyphenols（5-8）和单齿抑制剂5- ñ - ñ -alkylcarbamyloxyresorcinols（9-12）表明抑制效力如下：三齿抑制剂>二齿抑制剂>单齿抑制剂。三齿抑制剂，二齿抑制剂和单齿抑制剂的log k i和p K i值与烷基链长度线性相关，表明每种抑制作用的共同机理。同样，这些相关性的正斜率表明，长链抑制剂比短链抑制剂与酶的结合更紧密。三齿1，二齿5和单齿9分子对接胆固醇酯酶的X射线晶体结构表明顺式中

  DOI：

  10.1002/pro.2121

文献信息

• POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE, AND DISPLAY DEVICE
  申请人：FUJIFILM Corporation

  公开号：US20170226317A1

  公开（公告）日：2017-08-10

  A polarizing plate protective film which prevents deterioration of polarization performance in a high temperature, high humidity environment, and a polarizing plate and display device using the film including a compound represented by the following General Formula (I). (X-L n z General Formula (I) X represents a formyl group, a boronic acid group, or a group represented by the following General Formula (I-B) or a group represented by the following General Formula (I-C), where L represents a single bond or divalent linking group, and n represents an integer equal to or greater than 2. When n is 2, Z represents a single bond or a divalent group, and when n≧3, Z represents an n-valent group. R A and R B represent an alkyl group, a cycloalkyl group, an aryl group, or an acyl group. R A and R B may be bonded to each other to form a ring. * represents a bond to be bonded to L.

  一种偏光板保护膜，可防止在高温高湿环境中偏光性能的恶化，以及使用包括下述一般式（I）所代表的化合物的偏光板和显示装置。 （X-L n z 一般式（I） X代表甲酰基、硼酸基或由下述一般式（I-B）所代表的基团或由下述一般式（I-C）所代表的基团，其中L代表单键或二价连接基团，n代表大于或等于2的整数。当n为2时，Z代表单键或二价基团，当n≧3时，Z代表n价基团。 RA和RB代表烷基、环烷基、芳基或酰基。RA和RB可以相互连接形成环。*代表要连接到L的键。
• CELLULOSE ACYLATE FILM, NOVEL COMPOUND, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：FUJIFILM Corporation

  公开号：US20150361036A1

  公开（公告）日：2015-12-17

  A cellulose acylate film, which includes a compound denoted by general formula (I) below, the equivalent U of which, calculated as a value obtained by dividing the molecular weight of the compound by the number of divalent linking groups denoted by —O—C(═O)—NH— contained per molecule, is less than or equal to 515, wherein, in general formula (I), each of L 11 and L 21 independently denotes an optionally substituted alkylene group; each of L 12 and L 22 independently denotes a single bond, any one of or any combination of —O—, —NR 1 —, —S— and —C(═O)—; R 1 denotes a hydrogen atom or a substituent; each of n1 and n2 independently denotes an integer of 0 to 20, with at least either n1 or n2 being an integer of greater than or equal to 1. Q 1 -(L 12 -L 11 ) n1 -O—C(═O)—NH-(L 21 -L 22 ) n2 -Q 2 General formula (I)

  一种纤维素酰酸酯薄膜，包括下面的通用公式（I）表示的化合物，其当以将该化合物的分子量除以每分子中含有的二价连接基团—O—C(═O)—NH—的数量得到的值计算时等效U小于或等于515，其中，在通用公式（I）中，L11和L21中的每一个独立表示一个可选择取代的烷基基团；L12和L22中的每一个独立表示一个单键，任意一个或任意组合的—O—、—NR1—、—S—和—C(═O)—；R1表示氢原子或取代基；n1和n2中的每一个独立表示0到20的整数，其中n1或n2中至少有一个整数大于或等于1。Q1-(L12-L11)n1-O—C(═O)—NH-(L21-L22)n2-Q2通用公式（I）
• Cellulose acylate film, novel compound, polarizing plate and liquid crystal display device
  申请人：FUJIFILM Corporation

  公开号：US10040754B2

  公开（公告）日：2018-08-07

  A cellulose acylate film, which includes a compound denoted by general formula (I) below, the equivalent U of which, calculated as a value obtained by dividing the molecular weight of the compound by the number of divalent linking groups denoted by —O—C(═O)—NH— contained per molecule, is less than or equal to 515, wherein, in general formula (I), each of L11 and L21 independently denotes an optionally substituted alkylene group; each of L12 and L22 independently denotes a single bond, any one of or any combination of —O—, —NR1—, —S— and —C(═O)—; R1 denotes a hydrogen atom or a substituent; each of n1 and n2 independently denotes an integer of 0 to 20, with at least either n1 or n2 being an integer of greater than or equal to 1. Q1-(L12-L11)n1-O—C(═O)—NH-(L21-L22)n2-Q2  General formula (I)

  一种纤维素酰基化合物薄膜，它包括以下通式(I)表示的化合物，其当量U(通过将化合物的分子量除以每个分子所含的由-O-C(═O)-NH-表示的二价连接基团的数目而得到的值)小于或等于515，其中，在通式(I)中，L11和L21各自独立地表示任选取代的亚烷基；L12和L22各自独立地表示单键、-O-、-NR1-、-S-和-C(═O)-中的任意一个或任意组合； R1表示氢原子或取代基； n1和n2各自独立地表示0至20的整数，其中至少n1或n2之一是大于或等于1的整数。 Q1-(L12-L11)n1-O-C(═O)-NH-(L21-L22)n2-Q2 通式 (I)
• Cellulose ester film, polarizing plate, and liquid crystal display device
  申请人：FUJIFILM Corporation

  公开号：US10338290B2

  公开（公告）日：2019-07-02

  A cellulose ester film contains a compound having a structural unit denoted by —NR—(C═O)— in which R represents a hydrogen atom or a substituent, a surface having knoop hardness of greater than or equal to 210 N/mm2 is provided, and loss tangent tan δ at 25° C. is greater than or equal to 0.03.

  一种纤维素酯薄膜含有一种化合物，其结构单元用-NR-(C═O)-表示，其中R代表氢原子或取代基，表面硬度大于或等于210牛顿/平方毫米，25°C时的损耗正切tanδ大于或等于0.03。
• Cellulose acylate film, production method of cellulose acylate film, stack, polarizing plate, and liquid crystal display device
  申请人：FUJIFILM Corporation

  公开号：US10392484B2

  公开（公告）日：2019-08-27

  A cellulose acylate film includes cellulose acylate and a compound A which has a group represented by the formula (G) as defined herein and in which a value obtained by dividing a molecular weight of the compound by a number of the groups represented by formula (G) contained in the compound is 200 or less, and a content of the compound A is 15% by weight or more based on a content of the cellulose acylate, the iodine diffusion index X as defined herein is less than 0.005 and the iodine diffusion index Y as defined herein is 0.015 or more.

  一种纤维素酰基化合物薄膜包括纤维素酰基化合物和一种化合物 A，该化合物具有本文定义的式 (G) 所代表的基团，其中用化合物的分子量除以化合物中所含式 (G) 所代表的基团数所得的值等于或小于 200，且化合物 A 的含量为纤维素酰基化合物含量的 15%（按重量计）或以上，本文定义的碘扩散指数 X 小于 0.005 而本文定义的碘扩散指数 Y 为 0.015 或以上。