7-(4-hydroxy-3-methoxyphenyl)-7,9,10,11-tetrahydro-6H,8H-chromeno[4,3-b]chromene-6,8-dione | 1309477-46-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-(4-hydroxy-3-methoxyphenyl)-7,9,10,11-tetrahydro-6H,8H-chromeno[4,3-b]chromene-6,8-dione
• 英文别名: 7-(4-hydroxy-3-methoxyphenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione；7-(4-Hydroxy-3-methoxyphenyl)-7,9,10,11-tetrahydrochromeno[3,2-c]chromene-6,8-dione
• CAS: 1309477-46-0
• 化学式: C₂₃H₁₈O₆
• 分子量: 390.392
• InChiKey: LYRFEYIEWMJGRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-羟基香豆素 、 1,3-环己二酮 、 香草醛 在 五氯化铌 作用下， 以 1,2-二氯乙烷 、 乙腈 为溶剂， 反应 2.0h， 以75%的产率得到7-(4-hydroxy-3-methoxyphenyl)-7,9,10,11-tetrahydro-6H,8H-chromeno[4,3-b]chromene-6,8-dione
  参考文献：
  名称：

  五氯化铌促进多组分反应合成苯并[4,3-b]苯并二甲基亚砜的新方法

  摘要：

  由五氯化铌促进的4-羟基香豆素，芳基醛衍生物与1,3-环己二酮之间的多组分反应合成了铬诺[4,3-b]色烯衍生物。该新方法简单，经济高效，具有良好的底物通用性，产率高且可以在较短的反应时间内进行。

  DOI：

  10.1016/j.tetlet.2017.01.062

文献信息

• A novel sulfonic acid functionalized ionic liquid catalyzed multicomponent synthesis of 10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives in water
  作者：Zhiwei Chen、Qiang Zhu、Weike Su

  DOI：10.1016/j.tetlet.2011.03.059

  日期：2011.5

  Three-component reactions of 4-hydroxycoumarin, aldehydes, and cyclic 1,3-dicarbonyl compounds were prompted by novel sulfonic acid functionalized ionic liquids 1,3-dimethyl-2-oxo-1,3-bis(4-sulfobutyl)imidazolidine-1,3-diium hydrogen sulfate ([DMDBSI]center dot 2HSO(4)) in water at reflux temperature to provide a novel series of 10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives for the first time in high yields. (C) 2011 Elsevier Ltd. All rights reserved.
• Fe(DS)3, an efficient Lewis acid-surfactant-combined catalyst (LASC) for the one pot synthesis of chromeno[4,3-b]chromene derivatives by assembling the basic building blocks
  作者：Koyel Pradhan、Sanjay Paul、Asish R. Das

  DOI：10.1016/j.tetlet.2013.04.001

  日期：2013.6

  A highly efficient multicomponent heteroannulation protocol for the synthesis of a library of chromeno[4,3-b]chromene derivative has been developed by applying a Lewis acid-surfactant-combined catalyst (LASC) [Fe(DS)(3)]. The LASC converted the initially floating reaction mass into a homogeneous mixture, which on stirring became a turbid emulsion of colloidal aggregates. The shape and size of the colloidal aggregates are confirmed by optical microscopy and DLS. The aqueous reaction medium, dual role of the catalyst in aqueous media, easy recovery of the catalyst, and high yield make the protocol attractive, sustainable, and economical. (C) 2013 Elsevier Ltd. All rights reserved.