N,N'-bis(bromoacetyl)-L-lysine ethyl ester | 1012342-59-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-bis(bromoacetyl)-L-lysine ethyl ester
• 英文别名: ethyl (2S)-2,6-bis[(2-bromoacetyl)amino]hexanoate
• CAS: 1012342-59-4
• 化学式: C₁₂H₂₀Br₂N₂O₄
• 分子量: 416.11
• InChiKey: IKLBIFXOCXZGAM-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  84.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N'-bis(bromoacetyl)-L-lysine ethyl ester 、 N-[3-(二甲基氨基)丙基]辛酰胺 以 异丙醇 为溶剂， 反应 60.0h， 以94.4%的产率得到
  参考文献：
  名称：

  Synthesis and antimicrobial characterization of novel l-lysine gemini surfactants pended with reactive groups

  摘要：

  A series of novel quaternary ammonium gemini surfactants Of L-lysine containing ester group were synthesized with high yield rate. The antibacterial and antifungal activities of these gemini surfactants were evaluated by quantifying the minimal inhibitory concentration (MIC). The results indicated that the quaternary ammonium gemini surfactants exhibited improved activity against a broad spectrum of Gram-positive and Gram-negative bacteria as well as fungi. The pended ester group provides a reactive site for incorporating the surfactant into polymers, thus leading to the polymers with high antimicrobial efficiency. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.01.079
• 作为产物：
  描述：

  L-lysine ethyl ester dihydrochloride 、 溴乙酰溴 在 碳酸氢钠 、 sodium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 以15.4 g的产率得到N,N'-bis(bromoacetyl)-L-lysine ethyl ester
  参考文献：
  名称：

  Synthesis and antimicrobial characterization of novel l-lysine gemini surfactants pended with reactive groups

  摘要：

  A series of novel quaternary ammonium gemini surfactants Of L-lysine containing ester group were synthesized with high yield rate. The antibacterial and antifungal activities of these gemini surfactants were evaluated by quantifying the minimal inhibitory concentration (MIC). The results indicated that the quaternary ammonium gemini surfactants exhibited improved activity against a broad spectrum of Gram-positive and Gram-negative bacteria as well as fungi. The pended ester group provides a reactive site for incorporating the surfactant into polymers, thus leading to the polymers with high antimicrobial efficiency. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.01.079

文献信息

• Synthesis and antimicrobial characterization of novel l-lysine gemini surfactants pended with reactive groups
  作者：Hong Tan、Huining Xiao

  DOI：10.1016/j.tetlet.2008.01.079

  日期：2008.3

  A series of novel quaternary ammonium gemini surfactants Of L-lysine containing ester group were synthesized with high yield rate. The antibacterial and antifungal activities of these gemini surfactants were evaluated by quantifying the minimal inhibitory concentration (MIC). The results indicated that the quaternary ammonium gemini surfactants exhibited improved activity against a broad spectrum of Gram-positive and Gram-negative bacteria as well as fungi. The pended ester group provides a reactive site for incorporating the surfactant into polymers, thus leading to the polymers with high antimicrobial efficiency. (c) 2008 Elsevier Ltd. All rights reserved.