N-methylaminopentan-3-one | 87156-67-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-methylaminopentan-3-one
• 英文别名: 1-(Methylamino)pentan-3-one
• CAS: 87156-67-0
• 化学式: C₆H₁₃NO
• 分子量: 115.175
• InChiKey: OREAUOBVFKXSIE-UHFFFAOYSA-N

物化性质

• 沸点：
  172.7±23.0 °C(Predicted)
• 密度：
  0.862±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-甲基戊-4-烯-1-胺 在 盐酸 、 氧气 、 sodium chloride 、 copper dichloride 、 palladium dichloride 作用下， 以 水 为溶剂， 反应 3.5h， 以80%的产率得到1,2-dimethyl-1-pyrrolinium ion
  参考文献：
  名称：

  钯催化将氨基烯烃氧化成环状亚胺或烯胺和氨基酮

  摘要：

  Lesaminoalcenes du type CH 2 =CH(CH 2 ) n NH 2 (n=3,4) se cyclisent en pyrrolines-1 ou tetrahydro-3,4,5,6 pyridines dans les conditions du procede Wacker。Lesaminoalcenes avec un groupe amino secondaire donnent les imines cycliquesrespondantes, tandis que les alcenes avec un groupeamino tertiaire donnent desaminocetones

  DOI：

  10.1021/ja00361a023

文献信息

• [EN] SYNTHETIC N-ACETYL-MURAMIC ACID DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS D'ACIDE MURAMIQUE N-ACÉTYLÉ SYNTHÉTIQUES ET LEURS UTILISATIONS
  申请人：UNIV DELAWARE

  公开号：WO2016172615A1

  公开（公告）日：2016-10-27

  The present invention provides N-acetyl-muramic acid (NAM) derivatives having Formula I, wherein Xa is selected from the group consisting of X1-X59, Ya is selected from the group consisting of H, monophosphate, uridine diphosphate and ethyl azide linker prepared from 2-azido-ethanol, and Za is selected from the group consisting of OH, an ethylene diamine coupled fluorophore, a peptide and a peptide with an ethylene diamine coupled fluorophore, wherein the peptide is selected from the group consisting of a monopeptide, a dipeptide, a tripeptide and a pentapeptide. Also provided are methods for synthesizing NAM derivatives and methods for modulating Nod2 in cells, modifying bacterial cell wall or modulating innate immune response by a subject to bacterial cells upon exposure to NAM derivatives.

  本发明提供具有式I的N-乙酰-壳聚糖酸（NAM）衍生物，其中Xa选自X1-X59组，Ya选自H、磷酸单酯、尿苷二磷酸和由2-叠氮乙醇制备的乙基叠氮连接剂组，Za选自OH、乙二胺偶联的荧光素、肽和乙二胺偶联的肽，其中肽选自单肽、二肽、三肽和五肽组。还提供了合成NAM衍生物的方法以及通过暴露于NAM衍生物后调节细胞中Nod2、修改细菌细胞壁或调节受试者对细菌细胞的固有免疫反应的方法。
• PHTHALAMIDE-LANTHANIDE COMPLEXES FOR USE AS LUMINESCENT MARKERS
  申请人：Raymond Kenneth N.

  公开号：US20090023928A1

  公开（公告）日：2009-01-22

  The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.

  本发明提供了包含镧系金属离子和至少含有一个邻苯二酰胺基团的络合剂的发光镧系金属螯合物。还提供了包含本发明的邻苯二酰胺基团的探针，并利用本发明的配体和包含本发明的配体的探针的方法。
• AMIDE COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP1845090A1

  公开（公告）日：2007-10-17

  The present invention provides compounds usuful for prevention, treatment or allevation of diseases against which activation of the thrombopoietin receptor is effective. A compound represented by the formula (1): wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

  本发明提供的化合物可用于预防、治疗或减轻对血小板生成素受体激活有效的疾病。 由式（1）代表的化合物： 其中A、B、R1、L1、R2、L2、L3、Y、L4、R3和X与说明书中定义的相同，该化合物的同系物、原药或药学上可接受的盐或其溶液。
• SALICYLAMIDE-LANTHANIDE COMPLEXES FOR USE AS LUMINESCENT MARKERS
  申请人：Raymond Kenneth N.

  公开号：US20080293155A1

  公开（公告）日：2008-11-27

  The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
• PEPTIDIC PTH RECEPTOR AGONISTS
  申请人：Schteingart Claudio D.

  公开号：US20110195900A1

  公开（公告）日：2011-08-11

  Novel peptidic pth receptor agonists and methods of using the same are provided.