3-O-beta-D-Galactopyranuronosyl-D-galactose | 7268-75-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-O-beta-D-Galactopyranuronosyl-D-galactose
• 英文别名: 3,4,5-trihydroxy-6-[2,3,5-trihydroxy-6-(hydroxymethyl)oxan-4-yl]oxyoxane-2-carboxylic acid
• CAS: 7268-75-9
• 化学式: C₁₂H₂₀O₁₂
• 分子量: 356.28
• InChiKey: GGFHJVYVXSKMOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  207
• 氢给体数：
  8
• 氢受体数：
  12

文献信息

• Carbohydrate ligands that bind to IGM antibodies against myelin-associated glycoprotein
  申请人：UNIVERSITÄT BASEL

  公开号：US10662212B2

  公开（公告）日：2020-05-26

  The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer-1 (HNK-1) epitope that bind to anti-MAG (myelin-associated glycoprotein) IgM antibodies, and their use in diagnosis as well as for the treatment of anti-MAG neuropathy. In particular, the invention relates to disaccharides of formula (I) and (II) wherein Z is optionally substituted phenyl, heteroaryl, arylcarbonyl, or heteroarylmethyl, and to therapeutically acceptable polymers comprising a multitude of substitutents of formula (I) and/or formula (II), wherein Z is a bifunctional linker connecting the disaccharides to the polymer backbone.

  本发明涉及呈现与抗 MAG（髓鞘相关糖蛋白）IgM 抗体结合的最小人类天然杀手-1（HNK-1）表位的碳水化合物配体，以及它们在诊断和治疗抗 MAG 神经病变中的用途。特别是，本发明涉及式（I）和（II）的二糖，其中 Z 是任选取代的苯基、杂芳基、芳羰基或杂芳基甲基；本发明还涉及治疗上可接受的聚合物，包括式（I）和/或式（II）的多种取代基，其中 Z 是连接二糖和聚合物骨架的双官能团连接剂。
• Carbohydrate ligands that bind to IgM antibodies against myelin-associated glycoprotein
  申请人：UNIVERSITÄT BASEL

  公开号：US11220523B2

  公开（公告）日：2022-01-11

  The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer-1 (HNK-1) epitope that bind to anti-MAG (myelin-associated glycoprotein) IgM antibodies, and their use in diagnosis as well as for the treatment of anti-MAG neuropathy. In particular, the invention relates to disaccharides of formula (I) and (II) wherein Z is optionally substituted phenyl, heteroaryl, arylcarbonyl, or heteroarylmethyl, and to therapeutically acceptable polymers comprising a multitude of substituents of formula (I) and/or formula (II), wherein Z is a bifunctional linker connecting the disaccharides to the polymer backbone.

  本发明涉及呈现与抗 MAG（髓鞘相关糖蛋白）IgM 抗体结合的最小人类天然杀手-1（HNK-1）表位的碳水化合物配体，以及它们在诊断和治疗抗 MAG 神经病变中的用途。特别是，本发明涉及式（I）和（II）的二糖，其中 Z 是任选取代的苯基、杂芳基、芳羰基或杂芳基甲基；本发明还涉及治疗上可接受的聚合物，包括式（I）和/或式（II）的多种取代基，其中 Z 是连接二糖和聚合物骨架的双官能团连接剂。
• CARBOHYDRATE LIGANDS THAT BIND TO IGM ANTIBODIES AGAINST MYELIN-ASSOCIATED GLYCOPROTEIN
  申请人：Universität Basel

  公开号：EP3116887B1

  公开（公告）日：2021-02-17
• US9994605B2
  申请人：——

  公开号：US9994605B2

  公开（公告）日：2018-06-12