(-)-6-(3,5-Dihydroxy-6-methyltetrahydropyran-2-yloxy) heptanoic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (-)-6-(3,5-Dihydroxy-6-methyltetrahydropyran-2-yloxy) heptanoic acid
• 英文别名: 6-(3,5-dihydroxy-6-methyloxan-2-yl)oxyheptanoic acid
• 化学式: C₁₃H₂₄O₆
• 分子量: 276.33
• InChiKey: KBTQMAFDKPKMEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] 6R-(3,6-DIDEOXY-L-ARABINO-HEXOPYRANOSYLOXY)HEPTANOIC ACID, PREPARATION PROCESS FOR THE SAME AND DAUER EFFECT THEREOF<br/>[FR] ACIDE 6R-(3,6-DIDESOXY-L-ARABINO-HEXOPYRANOSYLOXY)HEPTANOIQUE, PROCEDE DE PREPARATION DE CET ACIDE ET EFFET DAUER DE CET ACIDE
  申请人：JUNG MANKIL

  公开号：WO2005075491A1

  公开（公告）日：2005-08-18

  The present invention relates to a determination of a stereochemistry, a synthesis and dauer effect of 6R-(3,6-dideoxy-L-arabino-hexopyranosyloxy) heptanoic acid as a pheromone isolated from the Caenorhabditis elegance related to suppress of aging and stress. It becomes possible to develop medical substances using the pheromone relating to aging, stress, metabolism, signal transfer system in vivo, and anti-cancer, obesity and a suppressing agent for aging and stress.

  本发明涉及一种从Caenorhabditis elegans中分离出的6R-(3,6-二去氧-L-阿拉伯糖基)庚酸酯素的立体化学确定、合成和抑制老化和应激的效果。利用与老化、应激、新陈代谢、体内信号传递系统以及抗癌、肥胖和抑制老化和应激的药剂相关的这种信息素，可以研发出医药物质。
• 6R-(3,6-dideoxy-l-Arabino-Hexopyranosyloxy) heptanoic acid, preparation process for the same and dauer effect thereof
  申请人：Jung Mankil

  公开号：US20060079465A1

  公开（公告）日：2006-04-13

  The present invention relates to a determination of a stereochemistry, a synthesis and dauer effect of 6R-(3,6-dideoxy-L-arabino-hexopyranosyloxy)heptanoic acid as a pheromone isolated from the Caenorhabditis elegance related to suppress of aging and stress. It becomes possible to develop medical substances using the pheromone relating to aging, stress, metabolism, signal transfer system in vivo, and anti-cancer, obesity and a suppressing agent for aging and stress.

  本发明涉及从秀丽隐杆线虫中分离出的一种信息素6R-(3,6-二脱氧-L-阿拉伯糖基)庚酸的立体化学确定、合成和持久效应，该信息素与抑制衰老和压力有关。使用与衰老、压力、体内代谢、信号传递系统以及抗癌、肥胖和抑制衰老和压力的药物有关的信息素，可以开发医学物质。
• 6R-(3,6-DIDEOXY-L-ARABINO-HEXOPYRANOSYLOXY) HEPTANOIC ACID, PREPARATION PROCESS FOR THE SAME AND DAUER EFFECT THEREOF
  申请人：Jung Mankil

  公开号：US20080188646A1

  公开（公告）日：2008-08-07

  The present invention relates to a determination of a stereochemistry, a synthesis and dauer effect of 6R-(3,6-dideoxy-L-arabino-hexopyranosyloxy)heptanoic acid as a pheromone isolated from the Caenorhabditis elegance related to suppress of aging and stress. It becomes possible to develop medical substances using the pheromone relating to aging, stress, metabolism, signal transfer system in vivo, and anti-cancer, obesity and a suppressing agent for aging and stress.

  本发明涉及从秀丽隐杆线虫中分离出的一种信息素6R-(3,6-二脱氧-L-阿拉伯糖基)庚酸的立体化学确定、合成和抑制衰老和压力相关性的达尔效应。利用与衰老、压力、体内代谢、信号传递系统、抗癌、肥胖以及抑制衰老和压力的药物相关的信息素，开发医药物质成为可能。
• Utility of nematode small molecules
  申请人：California Institute of Technology

  公开号：US10183963B2

  公开（公告）日：2019-01-22

  The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.

  本发明涉及使用某些调节化合物治疗免疫紊乱和/或炎症的方法。在一个实施方案中，本发明提供了一种通过施用包含治疗有效剂量的阿斯卡糖苷化合物、或阿斯卡糖苷化合物混合物、或含有至少一种阿斯卡糖苷的混合物的组合物来治疗免疫和炎症紊乱疾病的方法。
• Pharmacologically active novel dauer pheromone compound for controlling aging and stress and method for isolating and characterizing the same
  申请人：Paik Ki Young

  公开号：US20050075389A1

  公开（公告）日：2005-04-07

  The present invention discloses a method for effectively isolating and purifying a physiological active dauer pheromone compound having the following structural formula I related to aging and stress of C. elegans , and determination of the structure of such material. First, ethanol extract is prepared by completely concentrating a liquid medium with ethanol after culturing C. elegans on a S. basal liquid medium, and then this ethanol fraction is further extracted with ethyl acetate. Then, impurities are removed from ethyl acetate extract by a silica-gel adsorption chromatography and a pheromone extract is isolated and purified by amine column chromatographic procedures using various solvents as eluent. Finally, a pheromone compound having structural formula I is completely isolated and characterized by size-exclusion HPLC.

  本发明公开了一种方法，用于有效分离和纯化具有以下结构式 I 的生理活性寄生虫信息素化合物，该化合物与秀丽隐杆线虫的衰老和应激有关 秀丽隐杆线虫 并确定其结构的方法。首先，用乙醇完全浓缩培养后的液体培养基，制备乙醇提取物。 elegans 然后用乙酸乙酯进一步萃取乙醇提取物。然后，用硅胶凝胶吸附色谱法去除乙酸乙酯提取物中的杂质，再用胺柱色谱法分离和纯化信息素提取物。最后，完全分离出具有结构式 I 的信息素化合物，并通过尺寸排阻高效液相色谱法对其进行表征。