6-Methyl-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxane-2,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-Methyl-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxane-2,4,5-triol
• 化学式: C₁₂H₂₂O₉
• 分子量: 310.3
• InChiKey: LGZDMFLDPIGJEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  149
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• ANTI-TUMOR PHARMACEUTICAL APPLICATION OF PENTACYCLIC TRITERPENE SAPONIN COMPOUNDS OF SZECHUAN MELANDIUM ROOT
  申请人：Wang, Xueyong

  公开号：EP3156058A1

  公开（公告）日：2017-04-19

  The invention provides compounds of structural formula I or a salt thereof, and total saponins comprising such compounds in the preparation of anti-tumor agents. The present study of this invention showed that the compounds of formula I and the related total saponins had strong inhibitory effects on the proliferation of several human tumor cell lines, such as hepatocarcinoma, gastric cancer, colon cancer, breast cancer and melanoma cell lines, also the combination of structural formula I and the chemical agents could fairly well reduce toxicity and increase treatment effects.

  本发明提供了结构式I的化合物或其盐，以及由此类化合物组成的总皂苷，用于制备抗肿瘤药。本发明的研究表明，式Ⅰ化合物及相关总皂苷对多种人类肿瘤细胞株，如肝癌、胃癌、结肠癌、乳腺癌和黑色素瘤细胞株的增殖有较强的抑制作用，而且结构式Ⅰ与化学制剂的组合能很好地降低毒性，提高治疗效果。
• COMPOSITION CONTAINING PSEUDOMONAS AERUGINOSA CULTURE SOLUTION EXTRACT HAVING ANTIBIOTIC AND ANTISEPTIC ACTIVITIES, AND USE THEREOF
  申请人：JOINT CENTER FOR BIOSCIENCES

  公开号：US20170143771A1

  公开（公告）日：2017-05-25

  The present invention provides an antiseptic and antibiotic composition containing a Pseudomonas aeruginosa culture solution extract as an active ingredient. The present invention provides a composition for preventing or treating acne, containing a Pseudomonas aeruginosa culture solution extract as an active ingredient. The composition containing a Pseudomonas aeruginosa culture solution extract, of the present invention, exhibits a broad antibiotic spectrum and a high antioxidant effect against various bacteria, and the composition can be applied to a cosmetic composition such as a cosmetic product and can also be useful for antibiotic, sterilizing and antiseptic purposes in various fields such as food, medical supplies, agricultural chemicals and household items. The present invention identifies a specific active ingredient causing the antibiotic effect of a Pseudomonas aeruginosa culture solution extract, and provides the structure thereof.