7-hydroxy-3,5,6,8-tetramethoxy-3',4'-methylenedioxyflavone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 7-hydroxy-3,5,6,8-tetramethoxy-3',4'-methylenedioxyflavone
• 英文别名: 2-(1,3-Benzodioxol-5-yl)-7-hydroxy-3,5,6,8-tetramethoxy-4H-1-benzopyran-4-one；2-(1,3-benzodioxol-5-yl)-7-hydroxy-3,5,6,8-tetramethoxychromen-4-one
• 化学式: C₂₀H₁₈O₉
• 分子量: 402.358
• InChiKey: MRWINNLHVMLDLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  1-溴-3-甲基-2-丁烯 、 7-hydroxy-3,5,6,8-tetramethoxy-3',4'-methylenedioxyflavone 在 potassium carbonate 、 potassium iodide 作用下， 以 丙酮 为溶剂， 反应 2.0h， 以50%的产率得到7-(3-methylbut-2-enyloxy)-3,5,6,8-tetramethoxy-3',4'-methylenedioxyflavone
  参考文献：
  名称：

  Polyoxygenated Flavones from the Leaves of Comptonella microcarpa

  摘要：

  The leaves of Comptonella microcarpa have yielded one alkaloid, dictamnine, and four known polyoxygenated flavonoids, meliternatin, 3,5,8-trimethoxy-6,7-3',4'-dimethylenedioxyflavone, 7-(3-methylbut-2-enyloxy)-3,5,8-trimethoxy-3',4'-methylenedioxyflavone (3), 7-hydroxy-3,5,8-trimethoxy-3',4'methylenedioxyflavone. In addition, two new flavonoids were found whose structures were established on the basis of their spectral data as 7-hydroxy-3,5,6,8-tetramethoxy-3',4'-methylenedioxyflavone (1) and 7-(3-methylbut-2-enyloxy)-3,5,6,8-tetramethoxy-3',4'-methylenedioxyflavone (2).

  DOI：

  10.1021/np9900730

文献信息

• Polyoxygenated Flavones from the Leaves of <i>Comptonella microcarpa</i>
  作者：Corinne Girard、Frédéric Muyard、Françoise Bévalot、François Tillequin、Jacqueline Vaquette、Thiérry Sévenet、Marc Litaudon

  DOI：10.1021/np9900730

  日期：1999.8.1

  The leaves of Comptonella microcarpa have yielded one alkaloid, dictamnine, and four known polyoxygenated flavonoids, meliternatin, 3,5,8-trimethoxy-6,7-3',4'-dimethylenedioxyflavone, 7-(3-methylbut-2-enyloxy)-3,5,8-trimethoxy-3',4'-methylenedioxyflavone (3), 7-hydroxy-3,5,8-trimethoxy-3',4'methylenedioxyflavone. In addition, two new flavonoids were found whose structures were established on the basis of their spectral data as 7-hydroxy-3,5,6,8-tetramethoxy-3',4'-methylenedioxyflavone (1) and 7-(3-methylbut-2-enyloxy)-3,5,6,8-tetramethoxy-3',4'-methylenedioxyflavone (2).