5-(2-amino-1-hydroxyethyl)-2-[[5-carbamoyloxy-3-(3,6-diaminohexanoylamino)-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]amino]-4,5-dihydro-1H-imidazole-4-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(2-amino-1-hydroxyethyl)-2-[[5-carbamoyloxy-3-(3,6-diaminohexanoylamino)-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]amino]-4,5-dihydro-1H-imidazole-4-carboxylic acid
• 化学式: C₁₉H₃₆N₈O₉
• 分子量: 520.5
• InChiKey: AJUBASUIRHJEOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.2
• 重原子数：
  36
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  303
• 氢给体数：
  11
• 氢受体数：
  13

文献信息

• Novel lactam ring-opening enzyme and use thereof
  申请人：Takagi Hiroshi

  公开号：US20070203075A1

  公开（公告）日：2007-08-30

  An enzyme capable of reducing the antibiotic activity (i.e., toxicity) of streptothricin with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells is provided along with a streptothricin derivative having reduced toxicity with respect to eukaryotic cells while retaining antibiotic activity with respect to prokaryotic cells, and a manufacturing method thereof. By opening the lactam ring of streptothricin, a protein having the amino acid sequence according to SEQ ID NO: 2, 4, 6, 8, 10, 12, 14 or 16 of the invention can reduce the antibiotic activity of streptothricin D with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells.
• US7892784B2
  申请人：——

  公开号：US7892784B2

  公开（公告）日：2011-02-22